| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP51A1 | DHCR24 | ENSPPYP00000019976 | ENSPPYP00000001525 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | DHCR24 isoform 1. | 0.983 |
| CYP51A1 | DHCR7 | ENSPPYP00000019976 | ENSPPYP00000003422 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | DHCR7 isoform 1. | 0.898 |
| CYP51A1 | EBP | ENSPPYP00000019976 | ENSPPYP00000022734 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | EBP isoform 1. | 0.589 |
| CYP51A1 | HSD17B7 | ENSPPYP00000019976 | ENSPPYP00000000676 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | HSD17B7 isoform 2. | 0.907 |
| CYP51A1 | IDI1 | ENSPPYP00000019976 | ENSPPYP00000002358 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.927 |
| CYP51A1 | NSDHL | ENSPPYP00000019976 | ENSPPYP00000023318 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | NSDHL isoform 1; Belongs to the 3-beta-HSD family. | 0.950 |
| CYP51A1 | SC5D | ENSPPYP00000019976 | ENSPPYP00000004558 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.942 |
| CYP51A1 | TM7SF2 | ENSPPYP00000019976 | ENSPPYP00000003564 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | TM7SF2 isoform 10. | 0.985 |
| DHCR24 | CYP51A1 | ENSPPYP00000001525 | ENSPPYP00000019976 | DHCR24 isoform 1. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.983 |
| DHCR24 | DHCR7 | ENSPPYP00000001525 | ENSPPYP00000003422 | DHCR24 isoform 1. | DHCR7 isoform 1. | 0.991 |
| DHCR24 | EBP | ENSPPYP00000001525 | ENSPPYP00000022734 | DHCR24 isoform 1. | EBP isoform 1. | 0.960 |
| DHCR24 | HSD17B7 | ENSPPYP00000001525 | ENSPPYP00000000676 | DHCR24 isoform 1. | HSD17B7 isoform 2. | 0.962 |
| DHCR24 | IDI1 | ENSPPYP00000001525 | ENSPPYP00000002358 | DHCR24 isoform 1. | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.570 |
| DHCR24 | NSDHL | ENSPPYP00000001525 | ENSPPYP00000023318 | DHCR24 isoform 1. | NSDHL isoform 1; Belongs to the 3-beta-HSD family. | 0.713 |
| DHCR24 | SC5D | ENSPPYP00000001525 | ENSPPYP00000004558 | DHCR24 isoform 1. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.974 |
| DHCR24 | TM7SF2 | ENSPPYP00000001525 | ENSPPYP00000003564 | DHCR24 isoform 1. | TM7SF2 isoform 10. | 0.955 |
| DHCR7 | CYP51A1 | ENSPPYP00000003422 | ENSPPYP00000019976 | DHCR7 isoform 1. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.898 |
| DHCR7 | DHCR24 | ENSPPYP00000003422 | ENSPPYP00000001525 | DHCR7 isoform 1. | DHCR24 isoform 1. | 0.991 |
| DHCR7 | EBP | ENSPPYP00000003422 | ENSPPYP00000022734 | DHCR7 isoform 1. | EBP isoform 1. | 0.744 |
| DHCR7 | HSD17B7 | ENSPPYP00000003422 | ENSPPYP00000000676 | DHCR7 isoform 1. | HSD17B7 isoform 2. | 0.775 |
