| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | ATIC | ENSPPYP00000002911 | ENSPPYP00000014690 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.530 |
| ALDH18A1 | DARS2 | ENSPPYP00000002911 | ENSPPYP00000000568 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Aspartyl-tRNA synthetase 2, mitochondrial. | 0.582 |
| ALDH18A1 | EPRS1 | ENSPPYP00000002911 | ENSPPYP00000000215 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | EPRS isoform 1. | 0.791 |
| ALDH18A1 | FAAH2 | ENSPPYP00000002911 | ENSPPYP00000022841 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Fatty acid amide hydrolase 2. | 0.769 |
| ALDH18A1 | GATB | ENSPPYP00000002911 | ENSPPYP00000016899 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. | 0.910 |
| ALDH18A1 | GMPS | ENSPPYP00000002911 | ENSPPYP00000015909 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | GMP synthase [glutamine-hydrolyzing]. | 0.955 |
| ALDH18A1 | MRPL58 | ENSPPYP00000002911 | ENSPPYP00000009674 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Mitochondrial ribosomal protein L58. | 0.507 |
| ALDH18A1 | PC | ENSPPYP00000002911 | ENSPPYP00000003482 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.603 |
| ALDH18A1 | TMEM109 | ENSPPYP00000002911 | ENSPPYP00000003691 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Transmembrane protein 109. | 0.436 |
| ATIC | ALDH18A1 | ENSPPYP00000014690 | ENSPPYP00000002911 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.530 |
| ATIC | EPRS1 | ENSPPYP00000014690 | ENSPPYP00000000215 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | EPRS isoform 1. | 0.578 |
| ATIC | FAAH2 | ENSPPYP00000014690 | ENSPPYP00000022841 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Fatty acid amide hydrolase 2. | 0.755 |
| ATIC | GATB | ENSPPYP00000014690 | ENSPPYP00000016899 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. | 0.880 |
| ATIC | GMPS | ENSPPYP00000014690 | ENSPPYP00000015909 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | GMP synthase [glutamine-hydrolyzing]. | 0.809 |
| DARS2 | ALDH18A1 | ENSPPYP00000000568 | ENSPPYP00000002911 | Aspartyl-tRNA synthetase 2, mitochondrial. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.582 |
| DARS2 | EPRS1 | ENSPPYP00000000568 | ENSPPYP00000000215 | Aspartyl-tRNA synthetase 2, mitochondrial. | EPRS isoform 1. | 0.965 |
| DARS2 | FAAH2 | ENSPPYP00000000568 | ENSPPYP00000022841 | Aspartyl-tRNA synthetase 2, mitochondrial. | Fatty acid amide hydrolase 2. | 0.899 |
| DARS2 | GATB | ENSPPYP00000000568 | ENSPPYP00000016899 | Aspartyl-tRNA synthetase 2, mitochondrial. | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. | 0.997 |
| DARS2 | GMPS | ENSPPYP00000000568 | ENSPPYP00000015909 | Aspartyl-tRNA synthetase 2, mitochondrial. | GMP synthase [glutamine-hydrolyzing]. | 0.922 |
| EPRS1 | ALDH18A1 | ENSPPYP00000000215 | ENSPPYP00000002911 | EPRS isoform 1. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.791 |