DKFZp468G2216 protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	DKFZp468G2216	ENSPPYP00000015644	ENSPPYP00000022865	CTNNB1 isoform 2.	AR isoform 8.	0.947
CTNNB1	HSP90AB1	ENSPPYP00000015644	ENSPPYP00000018631	CTNNB1 isoform 2.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.527
DKFZp468G2216	CTNNB1	ENSPPYP00000022865	ENSPPYP00000015644	AR isoform 8.	CTNNB1 isoform 2.	0.947
DKFZp468G2216	ENSPPYP00000006214	ENSPPYP00000022865	ENSPPYP00000006214	AR isoform 8.	annotation not available	0.964
DKFZp468G2216	FKBP4	ENSPPYP00000022865	ENSPPYP00000004732	AR isoform 8.	Peptidylprolyl isomerase.	0.982
DKFZp468G2216	FKBP5	ENSPPYP00000022865	ENSPPYP00000018489	AR isoform 8.	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	0.971
DKFZp468G2216	HSP90AB1	ENSPPYP00000022865	ENSPPYP00000018631	AR isoform 8.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.982
DKFZp468G2216	KLK3	ENSPPYP00000022865	ENSPPYP00000011530	AR isoform 8.	Prostate-specific antigen isoform X1.	0.979
DKFZp468G2216	NCOA2	ENSPPYP00000022865	ENSPPYP00000024008	AR isoform 8.	Nuclear receptor coactivator.	0.971
DKFZp468G2216	NCOA3	ENSPPYP00000022865	ENSPPYP00000012407	AR isoform 8.	Nuclear receptor coactivator.	0.956
DKFZp468G2216	NCOR2	ENSPPYP00000022865	ENSPPYP00000005808	AR isoform 8.	NCOR2 isoform 6.	0.956
DKFZp468G2216	PTGES3	ENSPPYP00000022865	ENSPPYP00000005319	AR isoform 8.	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.964
ENSPPYP00000006214	DKFZp468G2216	ENSPPYP00000006214	ENSPPYP00000022865	annotation not available	AR isoform 8.	0.964
ENSPPYP00000006214	FKBP4	ENSPPYP00000006214	ENSPPYP00000004732	annotation not available	Peptidylprolyl isomerase.	0.882
ENSPPYP00000006214	FKBP5	ENSPPYP00000006214	ENSPPYP00000018489	annotation not available	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	0.856
ENSPPYP00000006214	HSP90AB1	ENSPPYP00000006214	ENSPPYP00000018631	annotation not available	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.904
ENSPPYP00000006214	PTGES3	ENSPPYP00000006214	ENSPPYP00000005319	annotation not available	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.914
FKBP4	DKFZp468G2216	ENSPPYP00000004732	ENSPPYP00000022865	Peptidylprolyl isomerase.	AR isoform 8.	0.982
FKBP4	ENSPPYP00000006214	ENSPPYP00000004732	ENSPPYP00000006214	Peptidylprolyl isomerase.	annotation not available	0.882
FKBP4	FKBP5	ENSPPYP00000004732	ENSPPYP00000018489	Peptidylprolyl isomerase.	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	0.995