| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EID1 | MAGEE2 | ENSPPYP00000007318 | ENSPPYP00000022931 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). | MAGE family member E2. | 0.518 |
| EID1 | NSMCE4A | ENSPPYP00000007318 | ENSPPYP00000003168 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.486 |
| MAGEE2 | EID1 | ENSPPYP00000022931 | ENSPPYP00000007318 | MAGE family member E2. | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). | 0.518 |
| MAGEE2 | NPAS4 | ENSPPYP00000022931 | ENSPPYP00000003503 | MAGE family member E2. | Neuronal PAS domain protein 4. | 0.515 |
| MAGEE2 | NSMCE1 | ENSPPYP00000022931 | ENSPPYP00000008152 | MAGE family member E2. | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | 0.857 |
| MAGEE2 | NSMCE2 | ENSPPYP00000022931 | ENSPPYP00000021177 | MAGE family member E2. | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | 0.814 |
| MAGEE2 | NSMCE4A | ENSPPYP00000022931 | ENSPPYP00000003168 | MAGE family member E2. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.843 |
| MAGEE2 | RAD21 | ENSPPYP00000022931 | ENSPPYP00000021128 | MAGE family member E2. | RAD21 cohesin complex component. | 0.501 |
| MAGEE2 | RAD21L1 | ENSPPYP00000022931 | ENSPPYP00000012126 | MAGE family member E2. | Double-strand-break repair protein rad21-like protein 1. | 0.501 |
| MAGEE2 | SMC5 | ENSPPYP00000022931 | ENSPPYP00000021594 | MAGE family member E2. | SMC5 isoform 1. | 0.835 |
| MAGEE2 | SMC6 | ENSPPYP00000022931 | ENSPPYP00000014101 | MAGE family member E2. | Structural maintenance of chromosomes 6. | 0.817 |
| MAGEE2 | TP53 | ENSPPYP00000022931 | ENSPPYP00000008923 | MAGE family member E2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.529 |
| NPAS4 | MAGEE2 | ENSPPYP00000003503 | ENSPPYP00000022931 | Neuronal PAS domain protein 4. | MAGE family member E2. | 0.515 |
| NSMCE1 | MAGEE2 | ENSPPYP00000008152 | ENSPPYP00000022931 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | MAGE family member E2. | 0.857 |
| NSMCE1 | NSMCE2 | ENSPPYP00000008152 | ENSPPYP00000021177 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | 0.997 |
| NSMCE1 | NSMCE4A | ENSPPYP00000008152 | ENSPPYP00000003168 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.992 |
| NSMCE1 | RAD21 | ENSPPYP00000008152 | ENSPPYP00000021128 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | RAD21 cohesin complex component. | 0.471 |
| NSMCE1 | RAD21L1 | ENSPPYP00000008152 | ENSPPYP00000012126 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | Double-strand-break repair protein rad21-like protein 1. | 0.448 |
| NSMCE1 | SMC5 | ENSPPYP00000008152 | ENSPPYP00000021594 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | SMC5 isoform 1. | 0.996 |
| NSMCE1 | SMC6 | ENSPPYP00000008152 | ENSPPYP00000014101 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | Structural maintenance of chromosomes 6. | 0.996 |
