FMR1 protein (Pongo abelii) - STRING interaction network

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FMR1

Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa)

Predicted Functional Partners:

CYFIP1

0.992

FXR1

0.990

CYFIP2

0.986

TDRD3

0.939

FXR2

0.929

NUFIP2

0.891

AGO1

0.844

DICER1

0.834

AGO2

0.834

PURA

0.832

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSPPYP00000001789	ENSPPYP00000021212	Argonaute RISC component 1; Belongs to the argonaute family.	Eukaryotic translation initiation factor 2C.	0.987
AGO1	DICER1	ENSPPYP00000001789	ENSPPYP00000006949	Argonaute RISC component 1; Belongs to the argonaute family.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.997
AGO1	FMR1	ENSPPYP00000001789	ENSPPYP00000023279	Argonaute RISC component 1; Belongs to the argonaute family.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...]	0.844
AGO1	FXR1	ENSPPYP00000001789	ENSPPYP00000016024	Argonaute RISC component 1; Belongs to the argonaute family.	FMR1 autosomal homolog 1.	0.614
AGO1	FXR2	ENSPPYP00000001789	ENSPPYP00000008919	Argonaute RISC component 1; Belongs to the argonaute family.	FXR2 isoform 2.	0.583
AGO2	AGO1	ENSPPYP00000021212	ENSPPYP00000001789	Eukaryotic translation initiation factor 2C.	Argonaute RISC component 1; Belongs to the argonaute family.	0.987
AGO2	CYFIP1	ENSPPYP00000021212	ENSPPYP00000007096	Eukaryotic translation initiation factor 2C.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.504
AGO2	DICER1	ENSPPYP00000021212	ENSPPYP00000006949	Eukaryotic translation initiation factor 2C.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.988
AGO2	FMR1	ENSPPYP00000021212	ENSPPYP00000023279	Eukaryotic translation initiation factor 2C.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...]	0.834
AGO2	FXR1	ENSPPYP00000021212	ENSPPYP00000016024	Eukaryotic translation initiation factor 2C.	FMR1 autosomal homolog 1.	0.752
AGO2	FXR2	ENSPPYP00000021212	ENSPPYP00000008919	Eukaryotic translation initiation factor 2C.	FXR2 isoform 2.	0.693
CYFIP1	AGO2	ENSPPYP00000007096	ENSPPYP00000021212	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Eukaryotic translation initiation factor 2C.	0.504
CYFIP1	CYFIP2	ENSPPYP00000007096	ENSPPYP00000017891	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	0.968
CYFIP1	FMR1	ENSPPYP00000007096	ENSPPYP00000023279	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...]	0.992
CYFIP1	FXR1	ENSPPYP00000007096	ENSPPYP00000016024	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	FMR1 autosomal homolog 1.	0.988
CYFIP1	FXR2	ENSPPYP00000007096	ENSPPYP00000008919	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	FXR2 isoform 2.	0.909
CYFIP1	NUFIP2	ENSPPYP00000007096	ENSPPYP00000009131	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	NUFIP2 isoform 1.	0.655
CYFIP2	CYFIP1	ENSPPYP00000017891	ENSPPYP00000007096	Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.968
CYFIP2	FMR1	ENSPPYP00000017891	ENSPPYP00000023279	Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...]	0.986
CYFIP2	FXR1	ENSPPYP00000017891	ENSPPYP00000016024	Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	FMR1 autosomal homolog 1.	0.988

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