| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHUK | IRAK1 | ENSPPYP00000002975 | ENSPPYP00000023353 | CHUK isoform 1. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| CHUK | IRAK2 | ENSPPYP00000002975 | ENSPPYP00000015274 | CHUK isoform 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.627 |
| CHUK | IRAK4 | ENSPPYP00000002975 | ENSPPYP00000005053 | CHUK isoform 1. | IRAK4 isoform 6. | 0.932 |
| CHUK | IRF7 | ENSPPYP00000002975 | ENSPPYP00000003337 | CHUK isoform 1. | IRF7 isoform 12. | 0.965 |
| CHUK | MAP3K7 | ENSPPYP00000002975 | ENSPPYP00000018861 | CHUK isoform 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.997 |
| CHUK | MYD88 | ENSPPYP00000002975 | ENSPPYP00000015673 | CHUK isoform 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.565 |
| CHUK | PELI2 | ENSPPYP00000002975 | ENSPPYP00000006640 | CHUK isoform 1. | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.680 |
| CHUK | TAB2 | ENSPPYP00000002975 | ENSPPYP00000019131 | CHUK isoform 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.976 |
| CHUK | TRAF6 | ENSPPYP00000002975 | ENSPPYP00000003845 | CHUK isoform 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
| IL1R1 | IRAK1 | ENSPPYP00000013505 | ENSPPYP00000023353 | Interleukin 1 receptor type 1. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| IL1R1 | IRAK2 | ENSPPYP00000013505 | ENSPPYP00000015274 | Interleukin 1 receptor type 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.877 |
| IL1R1 | IRAK4 | ENSPPYP00000013505 | ENSPPYP00000005053 | Interleukin 1 receptor type 1. | IRAK4 isoform 6. | 0.891 |
| IL1R1 | MYD88 | ENSPPYP00000013505 | ENSPPYP00000015673 | Interleukin 1 receptor type 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.984 |
| IL1R1 | TRAF6 | ENSPPYP00000013505 | ENSPPYP00000003845 | Interleukin 1 receptor type 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.951 |
| IRAK1 | CHUK | ENSPPYP00000023353 | ENSPPYP00000002975 | Interleukin 1 receptor associated kinase 1. | CHUK isoform 1. | 0.980 |
| IRAK1 | IL1R1 | ENSPPYP00000023353 | ENSPPYP00000013505 | Interleukin 1 receptor associated kinase 1. | Interleukin 1 receptor type 1. | 0.980 |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | IRF7 | ENSPPYP00000023353 | ENSPPYP00000003337 | Interleukin 1 receptor associated kinase 1. | IRF7 isoform 12. | 0.988 |
| IRAK1 | MAP3K7 | ENSPPYP00000023353 | ENSPPYP00000018861 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.991 |
