| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | CR201_G0037390 | ENSPPYP00000007036 | ENSPPYP00000010903 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | PIK3R2 isoform 1. | 0.964 |
| AKT1 | EGFR | ENSPPYP00000007036 | ENSPPYP00000019671 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Receptor protein-tyrosine kinase. | 0.896 |
| AKT1 | ERBB2 | ENSPPYP00000007036 | ENSPPYP00000009527 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Receptor protein-tyrosine kinase. | 0.548 |
| AKT1 | IRS4 | ENSPPYP00000007036 | ENSPPYP00000023087 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Insulin receptor substrate 4. | 0.692 |
| AKT1 | KIT | ENSPPYP00000007036 | ENSPPYP00000016492 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.554 |
| AKT1 | KRAS | ENSPPYP00000007036 | ENSPPYP00000004987 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | KRAS proto-oncogene, GTPase. | 0.664 |
| AKT1 | PIK3CA | ENSPPYP00000007036 | ENSPPYP00000023529 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.996 |
| AKT1 | PIK3R1 | ENSPPYP00000007036 | ENSPPYP00000017341 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.992 |
| AKT1 | PIK3R3 | ENSPPYP00000007036 | ENSPPYP00000001627 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | T0148502 isoform 1. | 0.955 |
| AKT1 | PTPN11 | ENSPPYP00000007036 | ENSPPYP00000005677 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.513 |
| CR201_G0037390 | AKT1 | ENSPPYP00000010903 | ENSPPYP00000007036 | PIK3R2 isoform 1. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.964 |
| CR201_G0037390 | EGFR | ENSPPYP00000010903 | ENSPPYP00000019671 | PIK3R2 isoform 1. | Receptor protein-tyrosine kinase. | 0.994 |
| CR201_G0037390 | ERBB2 | ENSPPYP00000010903 | ENSPPYP00000009527 | PIK3R2 isoform 1. | Receptor protein-tyrosine kinase. | 0.989 |
| CR201_G0037390 | IRS4 | ENSPPYP00000010903 | ENSPPYP00000023087 | PIK3R2 isoform 1. | Insulin receptor substrate 4. | 0.990 |
| CR201_G0037390 | KIT | ENSPPYP00000010903 | ENSPPYP00000016492 | PIK3R2 isoform 1. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.978 |
| CR201_G0037390 | KRAS | ENSPPYP00000010903 | ENSPPYP00000004987 | PIK3R2 isoform 1. | KRAS proto-oncogene, GTPase. | 0.951 |
| CR201_G0037390 | PIK3CA | ENSPPYP00000010903 | ENSPPYP00000023529 | PIK3R2 isoform 1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.999 |
| CR201_G0037390 | PIK3R1 | ENSPPYP00000010903 | ENSPPYP00000017341 | PIK3R2 isoform 1. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.997 |
| CR201_G0037390 | PIK3R3 | ENSPPYP00000010903 | ENSPPYP00000001627 | PIK3R2 isoform 1. | T0148502 isoform 1. | 0.996 |
| CR201_G0037390 | PTPN11 | ENSPPYP00000010903 | ENSPPYP00000005677 | PIK3R2 isoform 1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.979 |
