| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARAF | RAF1 | ENSPPYP00000022715 | ENSPPYP00000014975 | A-Raf proto-oncogene, serine/threonine kinase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.998 |
| ARAF | SGK1 | ENSPPYP00000022715 | ENSPPYP00000019064 | A-Raf proto-oncogene, serine/threonine kinase. | Non-specific serine/threonine protein kinase. | 0.614 |
| ARAF | TSC22D1 | ENSPPYP00000022715 | ENSPPYP00000006071 | A-Raf proto-oncogene, serine/threonine kinase. | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity); Belongs to the TSC-22/Dip/Bun family. | 0.675 |
| ARAF | TSC22D3 | ENSPPYP00000022715 | ENSPPYP00000023578 | A-Raf proto-oncogene, serine/threonine kinase. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcr [...] | 0.738 |
| ARAF | TSC22D4 | ENSPPYP00000022715 | ENSPPYP00000019518 | A-Raf proto-oncogene, serine/threonine kinase. | TSC22D4 isoform 2. | 0.514 |
| ARAF | WWP1 | ENSPPYP00000022715 | ENSPPYP00000021002 | A-Raf proto-oncogene, serine/threonine kinase. | E3 ubiquitin-protein ligase. | 0.722 |
| CR201_G0050832 | NRBP1 | ENSPPYP00000021257 | ENSPPYP00000014013 | NRBP2 isoform 6. | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.784 |
| CR201_G0050832 | TSC22D1 | ENSPPYP00000021257 | ENSPPYP00000006071 | NRBP2 isoform 6. | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity); Belongs to the TSC-22/Dip/Bun family. | 0.573 |
| CR201_G0050832 | TSC22D3 | ENSPPYP00000021257 | ENSPPYP00000023578 | NRBP2 isoform 6. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcr [...] | 0.784 |
| CR201_G0050832 | TSC22D4 | ENSPPYP00000021257 | ENSPPYP00000019518 | NRBP2 isoform 6. | TSC22D4 isoform 2. | 0.919 |
| ENSPPYP00000002458 | NRBP1 | ENSPPYP00000002458 | ENSPPYP00000014013 | annotation not available | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.492 |
| ENSPPYP00000002458 | TSC22D2 | ENSPPYP00000002458 | ENSPPYP00000015886 | annotation not available | TSC22 domain family member 2. | 0.711 |
| ENSPPYP00000002458 | TSC22D3 | ENSPPYP00000002458 | ENSPPYP00000023578 | annotation not available | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcr [...] | 0.701 |
| NRBP1 | CR201_G0050832 | ENSPPYP00000014013 | ENSPPYP00000021257 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | NRBP2 isoform 6. | 0.784 |
| NRBP1 | ENSPPYP00000002458 | ENSPPYP00000014013 | ENSPPYP00000002458 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | annotation not available | 0.492 |
| NRBP1 | TSC22D1 | ENSPPYP00000014013 | ENSPPYP00000006071 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity); Belongs to the TSC-22/Dip/Bun family. | 0.925 |
| NRBP1 | TSC22D2 | ENSPPYP00000014013 | ENSPPYP00000015886 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | TSC22 domain family member 2. | 0.954 |
| NRBP1 | TSC22D3 | ENSPPYP00000014013 | ENSPPYP00000023578 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcr [...] | 0.925 |
| NRBP1 | TSC22D4 | ENSPPYP00000014013 | ENSPPYP00000019518 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | TSC22D4 isoform 2. | 0.935 |
| RAF1 | ARAF | ENSPPYP00000014975 | ENSPPYP00000022715 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | A-Raf proto-oncogene, serine/threonine kinase. | 0.998 |
