| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABAT | ACSS1 | ENSPPYP00000008008 | ENSPPYP00000012045 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acetyl-coenzyme A synthetase. | 0.863 |
| ABAT | ACSS2 | ENSPPYP00000008008 | ENSPPYP00000012219 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | ACSS2 isoform 8. | 0.848 |
| ABAT | ALDH3A2 | ENSPPYP00000008008 | ENSPPYP00000023716 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.936 |
| ACSS1 | ABAT | ENSPPYP00000012045 | ENSPPYP00000008008 | Acetyl-coenzyme A synthetase. | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.863 |
| ACSS1 | ACSS2 | ENSPPYP00000012045 | ENSPPYP00000012219 | Acetyl-coenzyme A synthetase. | ACSS2 isoform 8. | 0.904 |
| ACSS1 | ALDH3A2 | ENSPPYP00000012045 | ENSPPYP00000023716 | Acetyl-coenzyme A synthetase. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.935 |
| ACSS2 | ABAT | ENSPPYP00000012219 | ENSPPYP00000008008 | ACSS2 isoform 8. | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.848 |
| ACSS2 | ACSS1 | ENSPPYP00000012219 | ENSPPYP00000012045 | ACSS2 isoform 8. | Acetyl-coenzyme A synthetase. | 0.904 |
| ACSS2 | ALDH3A2 | ENSPPYP00000012219 | ENSPPYP00000023716 | ACSS2 isoform 8. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.935 |
| AKR1A1 | AKR1B1 | ENSPPYP00000001636 | ENSPPYP00000020215 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | Aldo-keto reductase family 1 member B. | 0.818 |
| AKR1A1 | AKR1B10 | ENSPPYP00000001636 | ENSPPYP00000020216 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | Aldo-keto reductase family 1 member B10. | 0.809 |
| AKR1A1 | ALDH3A2 | ENSPPYP00000001636 | ENSPPYP00000023716 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.937 |
| AKR1B1 | AKR1A1 | ENSPPYP00000020215 | ENSPPYP00000001636 | Aldo-keto reductase family 1 member B. | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | 0.818 |
| AKR1B1 | AKR1B10 | ENSPPYP00000020215 | ENSPPYP00000020216 | Aldo-keto reductase family 1 member B. | Aldo-keto reductase family 1 member B10. | 0.945 |
| AKR1B1 | ALDH3A2 | ENSPPYP00000020215 | ENSPPYP00000023716 | Aldo-keto reductase family 1 member B. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.963 |
| AKR1B10 | AKR1A1 | ENSPPYP00000020216 | ENSPPYP00000001636 | Aldo-keto reductase family 1 member B10. | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | 0.809 |
| AKR1B10 | AKR1B1 | ENSPPYP00000020216 | ENSPPYP00000020215 | Aldo-keto reductase family 1 member B10. | Aldo-keto reductase family 1 member B. | 0.945 |
| AKR1B10 | ALDH3A2 | ENSPPYP00000020216 | ENSPPYP00000023716 | Aldo-keto reductase family 1 member B10. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.968 |
| AKR1B10 | MAOA | ENSPPYP00000020216 | ENSPPYP00000022677 | Aldo-keto reductase family 1 member B10. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.474 |
| AKR1B10 | MAOB | ENSPPYP00000020216 | ENSPPYP00000022680 | Aldo-keto reductase family 1 member B10. | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). | 0.548 |
