| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NADK | NADSYN1 | ENSPPYP00000002308 | ENSPPYP00000003421 | NADK isoform 1. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.956 |
| NADK | NUDT12 | ENSPPYP00000002308 | ENSPPYP00000017521 | NADK isoform 1. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.917 |
| NADK | SARM1 | ENSPPYP00000002308 | ENSPPYP00000009100 | NADK isoform 1. | Sterile alpha and TIR motif containing 1. | 0.928 |
| NADK | SIRT1 | ENSPPYP00000002308 | ENSPPYP00000002788 | NADK isoform 1. | SIRT1 isoform 1. | 0.920 |
| NADK | SIRT2 | ENSPPYP00000002308 | ENSPPYP00000023731 | NADK isoform 1. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] | 0.914 |
| NADK | SIRT4 | ENSPPYP00000002308 | ENSPPYP00000005727 | NADK isoform 1. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.914 |
| NADK | SIRT5 | ENSPPYP00000002308 | ENSPPYP00000018164 | NADK isoform 1. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.919 |
| NADK | SIRT6 | ENSPPYP00000002308 | ENSPPYP00000010537 | NADK isoform 1. | SIRT6 isoform 1. | 0.914 |
| NADK | SIRT7 | ENSPPYP00000002308 | ENSPPYP00000009825 | NADK isoform 1. | SIRT7 isoform 2. | 0.914 |
| NADSYN1 | NADK | ENSPPYP00000003421 | ENSPPYP00000002308 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NADK isoform 1. | 0.956 |
| NADSYN1 | NAMPT | ENSPPYP00000003421 | ENSPPYP00000020466 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.440 |
| NADSYN1 | NUDT12 | ENSPPYP00000003421 | ENSPPYP00000017521 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.975 |
| NADSYN1 | SARM1 | ENSPPYP00000003421 | ENSPPYP00000009100 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Sterile alpha and TIR motif containing 1. | 0.918 |
| NADSYN1 | SIRT1 | ENSPPYP00000003421 | ENSPPYP00000002788 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | SIRT1 isoform 1. | 0.940 |
| NADSYN1 | SIRT2 | ENSPPYP00000003421 | ENSPPYP00000023731 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] | 0.925 |
| NADSYN1 | SIRT4 | ENSPPYP00000003421 | ENSPPYP00000005727 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.925 |
| NADSYN1 | SIRT5 | ENSPPYP00000003421 | ENSPPYP00000018164 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.933 |
| NADSYN1 | SIRT6 | ENSPPYP00000003421 | ENSPPYP00000010537 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | SIRT6 isoform 1. | 0.925 |
| NADSYN1 | SIRT7 | ENSPPYP00000003421 | ENSPPYP00000009825 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | SIRT7 isoform 2. | 0.925 |
| NAMPT | NADSYN1 | ENSPPYP00000020466 | ENSPPYP00000003421 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.440 |
