SUMO2 protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIAS1	PIAS2	ENSPPYP00000007471	ENSPPYP00000010266	PIAS1 isoform 1.	Protein inhibitor of activated STAT 2.	0.702
PIAS1	PIAS4	ENSPPYP00000007471	ENSPPYP00000010535	PIAS1 isoform 1.	PIAS4 isoform 1.	0.652
PIAS1	SAE1	ENSPPYP00000007471	ENSPPYP00000011372	PIAS1 isoform 1.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.532
PIAS1	SENP1	ENSPPYP00000007471	ENSPPYP00000005082	PIAS1 isoform 1.	Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from [...]	0.753
PIAS1	SENP2	ENSPPYP00000007471	ENSPPYP00000016070	PIAS1 isoform 1.	Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...]	0.550
PIAS1	SUMO2	ENSPPYP00000007471	ENSPPYP00000023768	PIAS1 isoform 1.	Small ubiquitin-related modifier.	0.855
PIAS1	UBA2	ENSPPYP00000007471	ENSPPYP00000011014	PIAS1 isoform 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.470
PIAS1	UBE2I	ENSPPYP00000007471	ENSPPYP00000007864	PIAS1 isoform 1.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.992
PIAS2	PIAS1	ENSPPYP00000010266	ENSPPYP00000007471	Protein inhibitor of activated STAT 2.	PIAS1 isoform 1.	0.702
PIAS2	SAE1	ENSPPYP00000010266	ENSPPYP00000011372	Protein inhibitor of activated STAT 2.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.445
PIAS2	SENP1	ENSPPYP00000010266	ENSPPYP00000005082	Protein inhibitor of activated STAT 2.	Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from [...]	0.588
PIAS2	SENP2	ENSPPYP00000010266	ENSPPYP00000016070	Protein inhibitor of activated STAT 2.	Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...]	0.588
PIAS2	SUMO2	ENSPPYP00000010266	ENSPPYP00000023768	Protein inhibitor of activated STAT 2.	Small ubiquitin-related modifier.	0.767
PIAS2	UBA2	ENSPPYP00000010266	ENSPPYP00000011014	Protein inhibitor of activated STAT 2.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.494
PIAS2	UBE2I	ENSPPYP00000010266	ENSPPYP00000007864	Protein inhibitor of activated STAT 2.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.993
PIAS4	PIAS1	ENSPPYP00000010535	ENSPPYP00000007471	PIAS4 isoform 1.	PIAS1 isoform 1.	0.652
PIAS4	SAE1	ENSPPYP00000010535	ENSPPYP00000011372	PIAS4 isoform 1.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.463
PIAS4	SENP1	ENSPPYP00000010535	ENSPPYP00000005082	PIAS4 isoform 1.	Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from [...]	0.623
PIAS4	SENP2	ENSPPYP00000010535	ENSPPYP00000016070	PIAS4 isoform 1.	Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...]	0.539
PIAS4	SUMO2	ENSPPYP00000010535	ENSPPYP00000023768	PIAS4 isoform 1.	Small ubiquitin-related modifier.	0.833