PLXNC1 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FCRL5	PLXNC1	ENSPPYP00000000801	ENSPPYP00000023830	FCRL5 isoform 1.	PLXNC1 isoform 1.	0.754
FCRL5	VPS52	ENSPPYP00000000801	ENSPPYP00000019330	FCRL5 isoform 1.	VPS52 isoform 4.	0.626
MET	NRP1	ENSPPYP00000020106	ENSPPYP00000002562	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Neuropilin; Belongs to the neuropilin family.	0.480
MET	PLXNC1	ENSPPYP00000020106	ENSPPYP00000023830	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNC1 isoform 1.	0.715
MET	SEMA3A	ENSPPYP00000020106	ENSPPYP00000020009	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA3A isoform 1; Belongs to the semaphorin family.	0.498
MET	SEMA3B	ENSPPYP00000020106	ENSPPYP00000015497	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA3B isoform 6; Belongs to the semaphorin family.	0.538
MET	SEMA3E	ENSPPYP00000020106	ENSPPYP00000020010	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA3E isoform 1; Belongs to the semaphorin family.	0.482
MET	SEMA4D	ENSPPYP00000020106	ENSPPYP00000021695	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA4D isoform 10; Belongs to the semaphorin family.	0.804
MET	SEMA6A	ENSPPYP00000020106	ENSPPYP00000017566	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA6A isoform 1; Belongs to the semaphorin family.	0.524
MET	SEMA7A	ENSPPYP00000020106	ENSPPYP00000007529	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA7A isoform 1; Belongs to the semaphorin family.	0.482
NRP1	MET	ENSPPYP00000002562	ENSPPYP00000020106	Neuropilin; Belongs to the neuropilin family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.480
NRP1	PLXNC1	ENSPPYP00000002562	ENSPPYP00000023830	Neuropilin; Belongs to the neuropilin family.	PLXNC1 isoform 1.	0.800
NRP1	SEMA3A	ENSPPYP00000002562	ENSPPYP00000020009	Neuropilin; Belongs to the neuropilin family.	SEMA3A isoform 1; Belongs to the semaphorin family.	0.998
NRP1	SEMA3B	ENSPPYP00000002562	ENSPPYP00000015497	Neuropilin; Belongs to the neuropilin family.	SEMA3B isoform 6; Belongs to the semaphorin family.	0.994
NRP1	SEMA3E	ENSPPYP00000002562	ENSPPYP00000020010	Neuropilin; Belongs to the neuropilin family.	SEMA3E isoform 1; Belongs to the semaphorin family.	0.965
NRP1	SEMA4D	ENSPPYP00000002562	ENSPPYP00000021695	Neuropilin; Belongs to the neuropilin family.	SEMA4D isoform 10; Belongs to the semaphorin family.	0.457
NRP1	SEMA6A	ENSPPYP00000002562	ENSPPYP00000017566	Neuropilin; Belongs to the neuropilin family.	SEMA6A isoform 1; Belongs to the semaphorin family.	0.657
NRP1	SEMA7A	ENSPPYP00000002562	ENSPPYP00000007529	Neuropilin; Belongs to the neuropilin family.	SEMA7A isoform 1; Belongs to the semaphorin family.	0.439
PLXNC1	FCRL5	ENSPPYP00000023830	ENSPPYP00000000801	PLXNC1 isoform 1.	FCRL5 isoform 1.	0.754
PLXNC1	MET	ENSPPYP00000023830	ENSPPYP00000020106	PLXNC1 isoform 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.715