| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AASS | ALDH7A1 | ENSPPYP00000020131 | ENSPPYP00000023896 | AASS isoform 1. | ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family. | 0.953 |
| AASS | PHYKPL | ENSPPYP00000020131 | ENSPPYP00000018023 | AASS isoform 1. | PHYKPL isoform 3; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.930 |
| ABAT | ACSS1 | ENSPPYP00000008008 | ENSPPYP00000012045 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acetyl-coenzyme A synthetase. | 0.863 |
| ABAT | AGXT2 | ENSPPYP00000008008 | ENSPPYP00000017192 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.938 |
| ABAT | ALDH6A1 | ENSPPYP00000008008 | ENSPPYP00000006799 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aldehyde dehydrogenase 6 family member A1. | 0.962 |
| ABAT | ALDH7A1 | ENSPPYP00000008008 | ENSPPYP00000023896 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family. | 0.963 |
| ABAT | UPB1 | ENSPPYP00000008008 | ENSPPYP00000012992 | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide; Belongs to the carbon-nitrogen hydrolase superfamily. BUP family. | 0.952 |
| ACSS1 | ABAT | ENSPPYP00000012045 | ENSPPYP00000008008 | Acetyl-coenzyme A synthetase. | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.863 |
| ACSS1 | AGXT2 | ENSPPYP00000012045 | ENSPPYP00000017192 | Acetyl-coenzyme A synthetase. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.821 |
| ACSS1 | ALDH6A1 | ENSPPYP00000012045 | ENSPPYP00000006799 | Acetyl-coenzyme A synthetase. | Aldehyde dehydrogenase 6 family member A1. | 0.925 |
| ACSS1 | ALDH7A1 | ENSPPYP00000012045 | ENSPPYP00000023896 | Acetyl-coenzyme A synthetase. | ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family. | 0.930 |
| AGXT2 | ABAT | ENSPPYP00000017192 | ENSPPYP00000008008 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.938 |
| AGXT2 | ACSS1 | ENSPPYP00000017192 | ENSPPYP00000012045 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acetyl-coenzyme A synthetase. | 0.821 |
| AGXT2 | ALDH6A1 | ENSPPYP00000017192 | ENSPPYP00000006799 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aldehyde dehydrogenase 6 family member A1. | 0.936 |
| AGXT2 | ALDH7A1 | ENSPPYP00000017192 | ENSPPYP00000023896 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family. | 0.946 |
| AGXT2 | UPB1 | ENSPPYP00000017192 | ENSPPYP00000012992 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide; Belongs to the carbon-nitrogen hydrolase superfamily. BUP family. | 0.906 |
| AKR1A1 | ALDH7A1 | ENSPPYP00000001636 | ENSPPYP00000023896 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family. | 0.935 |
| ALDH6A1 | ABAT | ENSPPYP00000006799 | ENSPPYP00000008008 | Aldehyde dehydrogenase 6 family member A1. | ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.962 |
| ALDH6A1 | ACSS1 | ENSPPYP00000006799 | ENSPPYP00000012045 | Aldehyde dehydrogenase 6 family member A1. | Acetyl-coenzyme A synthetase. | 0.925 |
| ALDH6A1 | AGXT2 | ENSPPYP00000006799 | ENSPPYP00000017192 | Aldehyde dehydrogenase 6 family member A1. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.936 |
