| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSF3R | EPO | ENSPPYP00000001772 | ENSPPYP00000019531 | CSF3R isoform 3. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.682 |
| CSF3R | EPOR | ENSPPYP00000001772 | ENSPPYP00000024078 | CSF3R isoform 3. | Erythropoietin receptor; Receptor for erythropoietin. | 0.928 |
| CSF3R | GHR | ENSPPYP00000001772 | ENSPPYP00000017241 | CSF3R isoform 3. | Growth hormone receptor. | 0.902 |
| CSF3R | JAK1 | ENSPPYP00000001772 | ENSPPYP00000001481 | CSF3R isoform 3. | Tyrosine-protein kinase. | 0.976 |
| CSF3R | JAK2 | ENSPPYP00000001772 | ENSPPYP00000021551 | CSF3R isoform 3. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.954 |
| CSF3R | JAK3 | ENSPPYP00000001772 | ENSPPYP00000010896 | CSF3R isoform 3. | Tyrosine-protein kinase. | 0.942 |
| CSF3R | LEPR | ENSPPYP00000001772 | ENSPPYP00000001479 | CSF3R isoform 3. | Leptin receptor. | 0.900 |
| CSF3R | MPL | ENSPPYP00000001772 | ENSPPYP00000001679 | CSF3R isoform 3. | MPL isoform 2. | 0.925 |
| CSF3R | STAT5A | ENSPPYP00000001772 | ENSPPYP00000009439 | CSF3R isoform 3. | Signal transducer and activator of transcription. | 0.783 |
| CSF3R | STAT5B | ENSPPYP00000001772 | ENSPPYP00000009440 | CSF3R isoform 3. | Signal transducer and activator of transcription. | 0.778 |
| EPO | CSF3R | ENSPPYP00000019531 | ENSPPYP00000001772 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | CSF3R isoform 3. | 0.682 |
| EPO | EPOR | ENSPPYP00000019531 | ENSPPYP00000024078 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Erythropoietin receptor; Receptor for erythropoietin. | 0.992 |
| EPO | GHR | ENSPPYP00000019531 | ENSPPYP00000017241 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Growth hormone receptor. | 0.675 |
| EPO | JAK1 | ENSPPYP00000019531 | ENSPPYP00000001481 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.798 |
| EPO | JAK2 | ENSPPYP00000019531 | ENSPPYP00000021551 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.869 |
| EPO | JAK3 | ENSPPYP00000019531 | ENSPPYP00000010896 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.801 |
| EPO | LEPR | ENSPPYP00000019531 | ENSPPYP00000001479 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Leptin receptor. | 0.686 |
| EPO | MPL | ENSPPYP00000019531 | ENSPPYP00000001679 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | MPL isoform 2. | 0.750 |
| EPOR | CSF3R | ENSPPYP00000024078 | ENSPPYP00000001772 | Erythropoietin receptor; Receptor for erythropoietin. | CSF3R isoform 3. | 0.928 |
| EPOR | EPO | ENSPPYP00000024078 | ENSPPYP00000019531 | Erythropoietin receptor; Receptor for erythropoietin. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.992 |
