CR201_G0020693 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	CR201_G0020693	ENSPPYP00000009402	ENSPPYP00000024080	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	T0070593 isoform 1.	0.864
CR201_G0020693	BRCA1	ENSPPYP00000024080	ENSPPYP00000009402	T0070593 isoform 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.864
CR201_G0020693	ENSPPYP00000012086	ENSPPYP00000024080	ENSPPYP00000012086	T0070593 isoform 1.	annotation not available	0.887
CR201_G0020693	STUB1	ENSPPYP00000024080	ENSPPYP00000007837	T0070593 isoform 1.	STIP1 homology and U-box containing protein 1.	0.884
CR201_G0020693	TMEM189-UBE2V1	ENSPPYP00000024080	ENSPPYP00000012429	T0070593 isoform 1.	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.887
CR201_G0020693	TRIM21	ENSPPYP00000024080	ENSPPYP00000004143	T0070593 isoform 1.	TRIM21 isoform 1.	0.819
CR201_G0020693	TRIP12	ENSPPYP00000024080	ENSPPYP00000014809	T0070593 isoform 1.	TRIP12 isoform 4.	0.807
CR201_G0020693	UBA1	ENSPPYP00000024080	ENSPPYP00000022706	T0070593 isoform 1.	UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.913
CR201_G0020693	UBA6	ENSPPYP00000024080	ENSPPYP00000016457	T0070593 isoform 1.	UBA6 isoform 1.	0.813
CR201_G0020693	UBA7	ENSPPYP00000024080	ENSPPYP00000015508	T0070593 isoform 1.	UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.864
CR201_G0020693	UBE2V2	ENSPPYP00000024080	ENSPPYP00000020831	T0070593 isoform 1.	Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...]	0.849
ENSPPYP00000012086	CR201_G0020693	ENSPPYP00000012086	ENSPPYP00000024080	annotation not available	T0070593 isoform 1.	0.887
ENSPPYP00000012086	STUB1	ENSPPYP00000012086	ENSPPYP00000007837	annotation not available	STIP1 homology and U-box containing protein 1.	0.505
ENSPPYP00000012086	TMEM189-UBE2V1	ENSPPYP00000012086	ENSPPYP00000012429	annotation not available	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.981
ENSPPYP00000012086	TRIP12	ENSPPYP00000012086	ENSPPYP00000014809	annotation not available	TRIP12 isoform 4.	0.503
ENSPPYP00000012086	UBA1	ENSPPYP00000012086	ENSPPYP00000022706	annotation not available	UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.681
ENSPPYP00000012086	UBA6	ENSPPYP00000012086	ENSPPYP00000016457	annotation not available	UBA6 isoform 1.	0.681
ENSPPYP00000012086	UBA7	ENSPPYP00000012086	ENSPPYP00000015508	annotation not available	UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.681
ENSPPYP00000012086	UBE2V2	ENSPPYP00000012086	ENSPPYP00000020831	annotation not available	Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...]	0.574
STUB1	CR201_G0020693	ENSPPYP00000007837	ENSPPYP00000024080	STIP1 homology and U-box containing protein 1.	T0070593 isoform 1.	0.884