| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF5 | CR201_G0023353 | ENSPPYP00000020344 | ENSPPYP00000024112 | ARHGEF35 isoform 1. | ARHGEF17 isoform 1. | 0.516 |
| ARHGEF5 | RHOA | ENSPPYP00000020344 | ENSPPYP00000015522 | ARHGEF35 isoform 1. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.741 |
| ARHGEF5 | RHOC | ENSPPYP00000020344 | ENSPPYP00000001186 | ARHGEF35 isoform 1. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.611 |
| CR201_G0023353 | ARHGEF5 | ENSPPYP00000024112 | ENSPPYP00000020344 | ARHGEF17 isoform 1. | ARHGEF35 isoform 1. | 0.516 |
| CR201_G0023353 | NUAK2 | ENSPPYP00000024112 | ENSPPYP00000000331 | ARHGEF17 isoform 1. | NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | 0.570 |
| CR201_G0023353 | P2RY2 | ENSPPYP00000024112 | ENSPPYP00000004181 | ARHGEF17 isoform 1. | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | 0.501 |
| CR201_G0023353 | PTPN14 | ENSPPYP00000024112 | ENSPPYP00000000229 | ARHGEF17 isoform 1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.506 |
| CR201_G0023353 | RAB40B | ENSPPYP00000024112 | ENSPPYP00000009861 | ARHGEF17 isoform 1. | RAB40B, member RAS oncogene family. | 0.509 |
| CR201_G0023353 | RASL12 | ENSPPYP00000024112 | ENSPPYP00000007441 | ARHGEF17 isoform 1. | RAS like family 12. | 0.511 |
| CR201_G0023353 | RHOA | ENSPPYP00000024112 | ENSPPYP00000015522 | ARHGEF17 isoform 1. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.622 |
| CR201_G0023353 | RHOC | ENSPPYP00000024112 | ENSPPYP00000001186 | ARHGEF17 isoform 1. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.509 |
| CR201_G0023353 | TBRG1 | ENSPPYP00000024112 | ENSPPYP00000004590 | ARHGEF17 isoform 1. | Transforming growth factor beta regulator 1. | 0.599 |
| CR201_G0023353 | TSKU | ENSPPYP00000024112 | ENSPPYP00000004230 | ARHGEF17 isoform 1. | Tsukushi, small leucine rich proteoglycan. | 0.507 |
| NUAK2 | CR201_G0023353 | ENSPPYP00000000331 | ENSPPYP00000024112 | NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | ARHGEF17 isoform 1. | 0.570 |
| NUAK2 | PTPN14 | ENSPPYP00000000331 | ENSPPYP00000000229 | NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.517 |
| P2RY2 | CR201_G0023353 | ENSPPYP00000004181 | ENSPPYP00000024112 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | ARHGEF17 isoform 1. | 0.501 |
| P2RY2 | TBRG1 | ENSPPYP00000004181 | ENSPPYP00000004590 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | Transforming growth factor beta regulator 1. | 0.505 |
| P2RY2 | TSKU | ENSPPYP00000004181 | ENSPPYP00000004230 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | Tsukushi, small leucine rich proteoglycan. | 0.684 |
| PTPN14 | CR201_G0023353 | ENSPPYP00000000229 | ENSPPYP00000024112 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | ARHGEF17 isoform 1. | 0.506 |
| PTPN14 | NUAK2 | ENSPPYP00000000229 | ENSPPYP00000000331 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | 0.517 |
