| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DKK1 | FZD1 | ENSPPYP00000002828 | ENSPPYP00000019980 | Dickkopf-like protein 1. | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.526 |
| DKK1 | FZD4 | ENSPPYP00000002828 | ENSPPYP00000004289 | Dickkopf-like protein 1. | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.535 |
| DKK1 | FZD5 | ENSPPYP00000002828 | ENSPPYP00000014662 | Dickkopf-like protein 1. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.411 |
| DKK1 | LRP6 | ENSPPYP00000002828 | ENSPPYP00000024153 | Dickkopf-like protein 1. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.998 |
| DKK1 | SOST | ENSPPYP00000002828 | ENSPPYP00000009391 | Dickkopf-like protein 1. | SOST isoform 1. | 0.744 |
| DKK1 | WNT1 | ENSPPYP00000002828 | ENSPPYP00000005109 | Dickkopf-like protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.876 |
| DKK1 | WNT3 | ENSPPYP00000002828 | ENSPPYP00000009317 | Dickkopf-like protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.886 |
| DKK1 | WNT3A | ENSPPYP00000002828 | ENSPPYP00000000148 | Dickkopf-like protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.931 |
| DKK1 | WNT5A | ENSPPYP00000002828 | ENSPPYP00000015420 | Dickkopf-like protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.831 |
| FZD1 | DKK1 | ENSPPYP00000019980 | ENSPPYP00000002828 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Dickkopf-like protein 1. | 0.526 |
| FZD1 | FZD5 | ENSPPYP00000019980 | ENSPPYP00000014662 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.793 |
| FZD1 | FZD7 | ENSPPYP00000019980 | ENSPPYP00000014616 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.420 |
| FZD1 | LRP6 | ENSPPYP00000019980 | ENSPPYP00000024153 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.990 |
| FZD1 | SOST | ENSPPYP00000019980 | ENSPPYP00000009391 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | SOST isoform 1. | 0.429 |
| FZD1 | WNT1 | ENSPPYP00000019980 | ENSPPYP00000005109 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.990 |
| FZD1 | WNT3 | ENSPPYP00000019980 | ENSPPYP00000009317 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.908 |
| FZD1 | WNT3A | ENSPPYP00000019980 | ENSPPYP00000000148 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.966 |
| FZD1 | WNT5A | ENSPPYP00000019980 | ENSPPYP00000015420 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.995 |
| FZD4 | DKK1 | ENSPPYP00000004289 | ENSPPYP00000002828 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Dickkopf-like protein 1. | 0.535 |
| FZD4 | FZD5 | ENSPPYP00000004289 | ENSPPYP00000014662 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.571 |
