| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPPYP00000016227 | SURF4 | ENSPPYP00000016227 | ENSPPYP00000022130 | annotation not available | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | 0.695 |
| ENSPPYP00000016227 | TICAM1 | ENSPPYP00000016227 | ENSPPYP00000010561 | annotation not available | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.669 |
| ENSPPYP00000016227 | TMED10 | ENSPPYP00000016227 | ENSPPYP00000024352 | annotation not available | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.925 |
| ENSPPYP00000016227 | TMED2 | ENSPPYP00000016227 | ENSPPYP00000024232 | annotation not available | Transmembrane p24 trafficking protein 2. | 0.908 |
| ENSPPYP00000016227 | TMED3 | ENSPPYP00000016227 | ENSPPYP00000007613 | annotation not available | Transmembrane p24 trafficking protein 3. | 0.670 |
| ENSPPYP00000016227 | TMED7-TICAM2 | ENSPPYP00000016227 | ENSPPYP00000017557 | annotation not available | TICAM2 isoform 1. | 0.669 |
| SEC23A | TMED10 | ENSPPYP00000006547 | ENSPPYP00000024352 | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.653 |
| SEC23A | TMED2 | ENSPPYP00000006547 | ENSPPYP00000024232 | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Transmembrane p24 trafficking protein 2. | 0.815 |
| SURF4 | ENSPPYP00000016227 | ENSPPYP00000022130 | ENSPPYP00000016227 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | annotation not available | 0.695 |
| SURF4 | TICAM1 | ENSPPYP00000022130 | ENSPPYP00000010561 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.664 |
| SURF4 | TMED10 | ENSPPYP00000022130 | ENSPPYP00000024352 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.816 |
| SURF4 | TMED2 | ENSPPYP00000022130 | ENSPPYP00000024232 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | Transmembrane p24 trafficking protein 2. | 0.827 |
| SURF4 | TMED3 | ENSPPYP00000022130 | ENSPPYP00000007613 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | Transmembrane p24 trafficking protein 3. | 0.664 |
| SURF4 | TMED4 | ENSPPYP00000022130 | ENSPPYP00000019713 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | Transmembrane p24 trafficking protein 4. | 0.700 |
| SURF4 | TMED7-TICAM2 | ENSPPYP00000022130 | ENSPPYP00000017557 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | TICAM2 isoform 1. | 0.664 |
| SURF4 | TMED9 | ENSPPYP00000022130 | ENSPPYP00000023555 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | Transmembrane p24 trafficking protein 9. | 0.712 |
| TICAM1 | ENSPPYP00000016227 | ENSPPYP00000010561 | ENSPPYP00000016227 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | annotation not available | 0.669 |
| TICAM1 | SURF4 | ENSPPYP00000010561 | ENSPPYP00000022130 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. | 0.664 |
| TICAM1 | TMED10 | ENSPPYP00000010561 | ENSPPYP00000024352 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.832 |
| TICAM1 | TMED2 | ENSPPYP00000010561 | ENSPPYP00000024232 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Transmembrane p24 trafficking protein 2. | 0.861 |