| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOA1 | APOA4 | ENSPPYP00000004472 | ENSPPYP00000024275 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Apolipoprotein A4. | 0.889 |
| APOA1 | APOB | ENSPPYP00000004472 | ENSPPYP00000014082 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | APOB isoform 1. | 0.998 |
| APOA1 | APOC1 | ENSPPYP00000004472 | ENSPPYP00000011299 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Truncated apolipoprotein C-I, acidic form; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Mod [...] | 0.935 |
| APOA1 | APOC2 | ENSPPYP00000004472 | ENSPPYP00000011300 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Apolipoprotein C2. | 0.984 |
| APOA1 | APOC3 | ENSPPYP00000004472 | ENSPPYP00000004471 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Apolipoprotein C3. | 0.996 |
| APOA1 | APOE | ENSPPYP00000004472 | ENSPPYP00000011298 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Apolipoprotein E. | 0.987 |
| APOA1 | APOH | ENSPPYP00000004472 | ENSPPYP00000009611 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | APOH isoform 1. | 0.937 |
| APOA1 | APOM | ENSPPYP00000004472 | ENSPPYP00000018389 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). | 0.859 |
| APOA1 | CETP | ENSPPYP00000004472 | ENSPPYP00000008335 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.930 |
| APOA1 | LPL | ENSPPYP00000004472 | ENSPPYP00000020617 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.776 |
| APOA4 | APOA1 | ENSPPYP00000024275 | ENSPPYP00000004472 | Apolipoprotein A4. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). | 0.889 |
| APOA4 | APOB | ENSPPYP00000024275 | ENSPPYP00000014082 | Apolipoprotein A4. | APOB isoform 1. | 0.897 |
| APOA4 | APOC1 | ENSPPYP00000024275 | ENSPPYP00000011299 | Apolipoprotein A4. | Truncated apolipoprotein C-I, acidic form; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Mod [...] | 0.760 |
| APOA4 | APOC2 | ENSPPYP00000024275 | ENSPPYP00000011300 | Apolipoprotein A4. | Apolipoprotein C2. | 0.933 |
| APOA4 | APOC3 | ENSPPYP00000024275 | ENSPPYP00000004471 | Apolipoprotein A4. | Apolipoprotein C3. | 0.982 |
| APOA4 | APOE | ENSPPYP00000024275 | ENSPPYP00000011298 | Apolipoprotein A4. | Apolipoprotein E. | 0.878 |
| APOA4 | APOH | ENSPPYP00000024275 | ENSPPYP00000009611 | Apolipoprotein A4. | APOH isoform 1. | 0.622 |
| APOA4 | APOM | ENSPPYP00000024275 | ENSPPYP00000018389 | Apolipoprotein A4. | Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). | 0.705 |
| APOA4 | CETP | ENSPPYP00000024275 | ENSPPYP00000008335 | Apolipoprotein A4. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.768 |
| APOA4 | LPL | ENSPPYP00000024275 | ENSPPYP00000020617 | Apolipoprotein A4. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.649 |
