STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (926 aa)    
Predicted Functional Partners:
ITSN2
ITSN2 isoform 3.
   
0.995
EPN1
EPN1 isoform 2.
   
 0.993
EGFR
Receptor protein-tyrosine kinase.
    
 0.993
EPS15
Epidermal growth factor receptor pathway substrate 15.
  
 
0.984
ITSN1
ITSN1 isoform 4.
   
0.969
EPN3
EPN3 isoform 1.
   
 0.965
STON2
STON2 isoform 2; Belongs to the Stoned B family.
    
 0.956
AP2S1
AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
 0.955
GRB2
Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.
    
 0.928
PDGFRA
Platelet-derived growth factor receptor alpha.
    
 0.914
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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