node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH16A1 | BHMT | ENSPPYP00000011474 | ENSPPYP00000017424 | T0103156 isoform 1. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | 0.767 |
ALDH16A1 | PAAF1 | ENSPPYP00000011474 | ENSPPYP00000004190 | T0103156 isoform 1. | Proteasomal ATPase associated factor 1. | 0.746 |
ALDH16A1 | SLC2A9 | ENSPPYP00000011474 | ENSPPYP00000016315 | T0103156 isoform 1. | Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). | 0.658 |
ALDH16A1 | SPG21 | ENSPPYP00000011474 | ENSPPYP00000024383 | T0103156 isoform 1. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.799 |
ALDH16A1 | USP1 | ENSPPYP00000011474 | ENSPPYP00000001497 | T0103156 isoform 1. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.738 |
BHMT | ALDH16A1 | ENSPPYP00000017424 | ENSPPYP00000011474 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | T0103156 isoform 1. | 0.767 |
BHMT | PAAF1 | ENSPPYP00000017424 | ENSPPYP00000004190 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Proteasomal ATPase associated factor 1. | 0.721 |
BHMT | SLC2A9 | ENSPPYP00000017424 | ENSPPYP00000016315 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). | 0.727 |
BHMT | SPG21 | ENSPPYP00000017424 | ENSPPYP00000024383 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.585 |
BHMT | USP1 | ENSPPYP00000017424 | ENSPPYP00000001497 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.724 |
GJC2 | PNPLA6 | ENSPPYP00000000142 | ENSPPYP00000010625 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). | 0.679 |
GJC2 | SPART | ENSPPYP00000000142 | ENSPPYP00000006015 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | SPART isoform 1. | 0.572 |
GJC2 | SPG11 | ENSPPYP00000000142 | ENSPPYP00000007288 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | SPG11 isoform 3. | 0.582 |
GJC2 | SPG21 | ENSPPYP00000000142 | ENSPPYP00000024383 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.635 |
GJC2 | SPG7 | ENSPPYP00000000142 | ENSPPYP00000008641 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | SPG7 matrix AAA peptidase subunit, paraplegin. | 0.588 |
PAAF1 | ALDH16A1 | ENSPPYP00000004190 | ENSPPYP00000011474 | Proteasomal ATPase associated factor 1. | T0103156 isoform 1. | 0.746 |
PAAF1 | BHMT | ENSPPYP00000004190 | ENSPPYP00000017424 | Proteasomal ATPase associated factor 1. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | 0.721 |
PAAF1 | SLC2A9 | ENSPPYP00000004190 | ENSPPYP00000016315 | Proteasomal ATPase associated factor 1. | Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). | 0.680 |
PAAF1 | SPG21 | ENSPPYP00000004190 | ENSPPYP00000024383 | Proteasomal ATPase associated factor 1. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.645 |
PAAF1 | USP1 | ENSPPYP00000004190 | ENSPPYP00000001497 | Proteasomal ATPase associated factor 1. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.738 |