ENSPPYP00000024459 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

ENSPPYP00000024459

annotation not available (494 aa)

Predicted Functional Partners:

GAK

0.930

DNAJA2

0.777

DNAJA4

0.766

DNAJA1

0.765

DNAJB9

0.729

DNAJC5B

0.718

DNAJB1

0.711

DNAJB4

0.709

DNAJB5

0.704

DNAJB7

0.693

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJA1	DNAJA2	ENSPPYP00000021446	ENSPPYP00000008269	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member A2.	0.802
DNAJA1	DNAJA4	ENSPPYP00000021446	ENSPPYP00000007596	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member A4.	0.839
DNAJA1	DNAJB1	ENSPPYP00000021446	ENSPPYP00000010811	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member B1.	0.782
DNAJA1	DNAJB4	ENSPPYP00000021446	ENSPPYP00000001411	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.744
DNAJA1	DNAJB5	ENSPPYP00000021446	ENSPPYP00000022281	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member B5.	0.679
DNAJA1	DNAJB7	ENSPPYP00000021446	ENSPPYP00000013234	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member B7.	0.525
DNAJA1	DNAJB9	ENSPPYP00000021446	ENSPPYP00000020080	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similar [...]	0.686
DNAJA1	DNAJC5B	ENSPPYP00000021446	ENSPPYP00000020900	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DNAJC5B isoform 1.	0.407
DNAJA1	ENSPPYP00000024459	ENSPPYP00000021446	ENSPPYP00000024459	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	annotation not available	0.765
DNAJA1	GAK	ENSPPYP00000021446	ENSPPYP00000016219	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	GAK isoform 7.	0.406
DNAJA2	DNAJA1	ENSPPYP00000008269	ENSPPYP00000021446	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	0.802
DNAJA2	DNAJA4	ENSPPYP00000008269	ENSPPYP00000007596	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ heat shock protein family (Hsp40) member A4.	0.739
DNAJA2	DNAJB1	ENSPPYP00000008269	ENSPPYP00000010811	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ heat shock protein family (Hsp40) member B1.	0.752
DNAJA2	DNAJB4	ENSPPYP00000008269	ENSPPYP00000001411	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.770
DNAJA2	DNAJB5	ENSPPYP00000008269	ENSPPYP00000022281	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ heat shock protein family (Hsp40) member B5.	0.709
DNAJA2	DNAJB7	ENSPPYP00000008269	ENSPPYP00000013234	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ heat shock protein family (Hsp40) member B7.	0.566
DNAJA2	DNAJB9	ENSPPYP00000008269	ENSPPYP00000020080	DnaJ heat shock protein family (Hsp40) member A2.	DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similar [...]	0.691
DNAJA2	DNAJC5B	ENSPPYP00000008269	ENSPPYP00000020900	DnaJ heat shock protein family (Hsp40) member A2.	DNAJC5B isoform 1.	0.415
DNAJA2	ENSPPYP00000024459	ENSPPYP00000008269	ENSPPYP00000024459	DnaJ heat shock protein family (Hsp40) member A2.	annotation not available	0.777
DNAJA2	GAK	ENSPPYP00000008269	ENSPPYP00000016219	DnaJ heat shock protein family (Hsp40) member A2.	GAK isoform 7.	0.406