STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)    
Predicted Functional Partners:
NOTCH3
NOTCH3 isoform 1.
    
0.998
NOTCH1
NOTCH1 isoform 1.
   
0.993
NOTCH4
NOTCH4 isoform 1.
   
0.991
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
  
  
0.949
NOTCH2
NOTCH2 isoform 2.
   
0.927
DLL3
Delta like canonical Notch ligand 3.
     
0.907
ENSPPYP00000018739
annotation not available
   
0.844
RBPJ
Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]
    
 0.702
ENSPPYP00000022269
annotation not available
    
 0.702
HEY1
Hes related family bHLH transcription factor with YRPW motif 1.
    
 0.660
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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