| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCKDHB | CS | ENSPPYP00000018803 | ENSPPYP00000005303 | BCKDHB isoform 1. | Citrate synthase, mitochondrial isoform X1. | 0.760 |
| BCKDHB | DHTKD1 | ENSPPYP00000018803 | ENSPPYP00000003298 | BCKDHB isoform 1. | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.584 |
| BCKDHB | DLAT | ENSPPYP00000018803 | ENSPPYP00000004435 | BCKDHB isoform 1. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.911 |
| BCKDHB | DLD | ENSPPYP00000018803 | ENSPPYP00000020072 | BCKDHB isoform 1. | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.998 |
| BCKDHB | ENSPPYP00000024659 | ENSPPYP00000018803 | ENSPPYP00000024659 | BCKDHB isoform 1. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.846 |
| BCKDHB | OGDH | ENSPPYP00000018803 | ENSPPYP00000019712 | BCKDHB isoform 1. | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] | 0.766 |
| BCKDHB | OGDHL | ENSPPYP00000018803 | ENSPPYP00000002634 | BCKDHB isoform 1. | 2-oxoglutarate dehydrogenase-like, mitochondrial. | 0.730 |
| BCKDHB | PDHB | ENSPPYP00000018803 | ENSPPYP00000015393 | BCKDHB isoform 1. | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.511 |
| BCKDHB | PDHX | ENSPPYP00000018803 | ENSPPYP00000003859 | BCKDHB isoform 1. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.934 |
| BCKDHB | SUCLG1 | ENSPPYP00000018803 | ENSPPYP00000013652 | BCKDHB isoform 1. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.535 |
| CS | BCKDHB | ENSPPYP00000005303 | ENSPPYP00000018803 | Citrate synthase, mitochondrial isoform X1. | BCKDHB isoform 1. | 0.760 |
| CS | DHTKD1 | ENSPPYP00000005303 | ENSPPYP00000003298 | Citrate synthase, mitochondrial isoform X1. | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.813 |
| CS | DLAT | ENSPPYP00000005303 | ENSPPYP00000004435 | Citrate synthase, mitochondrial isoform X1. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.992 |
| CS | DLD | ENSPPYP00000005303 | ENSPPYP00000020072 | Citrate synthase, mitochondrial isoform X1. | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.908 |
| CS | ENSPPYP00000024659 | ENSPPYP00000005303 | ENSPPYP00000024659 | Citrate synthase, mitochondrial isoform X1. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.909 |
| CS | OGDH | ENSPPYP00000005303 | ENSPPYP00000019712 | Citrate synthase, mitochondrial isoform X1. | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] | 0.942 |
| CS | OGDHL | ENSPPYP00000005303 | ENSPPYP00000002634 | Citrate synthase, mitochondrial isoform X1. | 2-oxoglutarate dehydrogenase-like, mitochondrial. | 0.875 |
| CS | PDHB | ENSPPYP00000005303 | ENSPPYP00000015393 | Citrate synthase, mitochondrial isoform X1. | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.880 |
| CS | PDHX | ENSPPYP00000005303 | ENSPPYP00000003859 | Citrate synthase, mitochondrial isoform X1. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.891 |
| CS | SUCLG1 | ENSPPYP00000005303 | ENSPPYP00000013652 | Citrate synthase, mitochondrial isoform X1. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.933 |
