| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HTRA2 | MCU | ENSPPYP00000013676 | ENSPPYP00000002730 | HtrA serine peptidase 2. | Mitochondrial calcium uniporter. | 0.801 |
| HTRA2 | MICU1 | ENSPPYP00000013676 | ENSPPYP00000002731 | HtrA serine peptidase 2. | Mitochondrial calcium uptake 1. | 0.864 |
| HTRA2 | MICU2 | ENSPPYP00000013676 | ENSPPYP00000024750 | HtrA serine peptidase 2. | MICU2 isoform 2. | 0.870 |
| HTRA2 | NDUFA8 | ENSPPYP00000013676 | ENSPPYP00000022282 | HtrA serine peptidase 2. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.853 |
| HTRA2 | NDUFB10 | ENSPPYP00000013676 | ENSPPYP00000007895 | HtrA serine peptidase 2. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.853 |
| HTRA2 | NDUFB7 | ENSPPYP00000013676 | ENSPPYP00000010813 | HtrA serine peptidase 2. | NADH:ubiquinone oxidoreductase subunit B7. | 0.841 |
| HTRA2 | PARL | ENSPPYP00000013676 | ENSPPYP00000024436 | HtrA serine peptidase 2. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.616 |
| HTRA2 | PHB2 | ENSPPYP00000013676 | ENSPPYP00000004803 | HtrA serine peptidase 2. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.766 |
| HTRA2 | TIMM13 | ENSPPYP00000013676 | ENSPPYP00000010494 | HtrA serine peptidase 2. | Translocase of inner mitochondrial membrane 13; Belongs to the small Tim family. | 0.837 |
| MCU | HTRA2 | ENSPPYP00000002730 | ENSPPYP00000013676 | Mitochondrial calcium uniporter. | HtrA serine peptidase 2. | 0.801 |
| MCU | MICU1 | ENSPPYP00000002730 | ENSPPYP00000002731 | Mitochondrial calcium uniporter. | Mitochondrial calcium uptake 1. | 0.999 |
| MCU | MICU2 | ENSPPYP00000002730 | ENSPPYP00000024750 | Mitochondrial calcium uniporter. | MICU2 isoform 2. | 0.993 |
| MCU | NDUFA8 | ENSPPYP00000002730 | ENSPPYP00000022282 | Mitochondrial calcium uniporter. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.825 |
| MCU | NDUFB10 | ENSPPYP00000002730 | ENSPPYP00000007895 | Mitochondrial calcium uniporter. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.816 |
| MCU | NDUFB7 | ENSPPYP00000002730 | ENSPPYP00000010813 | Mitochondrial calcium uniporter. | NADH:ubiquinone oxidoreductase subunit B7. | 0.823 |
| MCU | PARL | ENSPPYP00000002730 | ENSPPYP00000024436 | Mitochondrial calcium uniporter. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.766 |
| MCU | PHB2 | ENSPPYP00000002730 | ENSPPYP00000004803 | Mitochondrial calcium uniporter. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.913 |
| MCU | SMDT1 | ENSPPYP00000002730 | ENSPPYP00000013268 | Mitochondrial calcium uniporter. | Single-pass membrane protein with aspartate rich tail 1. | 0.996 |
| MCU | TIMM13 | ENSPPYP00000002730 | ENSPPYP00000010494 | Mitochondrial calcium uniporter. | Translocase of inner mitochondrial membrane 13; Belongs to the small Tim family. | 0.815 |
| MICU1 | HTRA2 | ENSPPYP00000002731 | ENSPPYP00000013676 | Mitochondrial calcium uptake 1. | HtrA serine peptidase 2. | 0.864 |
