TAOK3 protein (Pongo abelii) - STRING interaction network

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TAOK3

Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...] (914 aa)

Predicted Functional Partners:

MAP2K3

0.918

MAP2K6

0.918

TAOK2

0.917

TRIB3

0.860

FLNC

0.635

IGFBP3

0.473

IGFBP5

0.421

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FLNC	TAOK3	ENSPPYP00000020178	ENSPPYP00000024760	FLNC isoform 2.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.635
IGFBP3	TAOK2	ENSPPYP00000019699	ENSPPYP00000008196	Insulin like growth factor binding protein 3.	TAOK2 isoform 1.	0.481
IGFBP3	TAOK3	ENSPPYP00000019699	ENSPPYP00000024760	Insulin like growth factor binding protein 3.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.473
IGFBP5	TAOK2	ENSPPYP00000014701	ENSPPYP00000008196	IGFBP5 isoform 1.	TAOK2 isoform 1.	0.421
IGFBP5	TAOK3	ENSPPYP00000014701	ENSPPYP00000024760	IGFBP5 isoform 1.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.421
MAP2K3	MAP2K6	ENSPPYP00000009080	ENSPPYP00000009634	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.995
MAP2K3	TAOK2	ENSPPYP00000009080	ENSPPYP00000008196	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	TAOK2 isoform 1.	0.969
MAP2K3	TAOK3	ENSPPYP00000009080	ENSPPYP00000024760	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.918
MAP2K6	MAP2K3	ENSPPYP00000009634	ENSPPYP00000009080	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.995
MAP2K6	TAOK2	ENSPPYP00000009634	ENSPPYP00000008196	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	TAOK2 isoform 1.	0.953
MAP2K6	TAOK3	ENSPPYP00000009634	ENSPPYP00000024760	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.918
TAOK2	IGFBP3	ENSPPYP00000008196	ENSPPYP00000019699	TAOK2 isoform 1.	Insulin like growth factor binding protein 3.	0.481
TAOK2	IGFBP5	ENSPPYP00000008196	ENSPPYP00000014701	TAOK2 isoform 1.	IGFBP5 isoform 1.	0.421
TAOK2	MAP2K3	ENSPPYP00000008196	ENSPPYP00000009080	TAOK2 isoform 1.	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.969
TAOK2	MAP2K6	ENSPPYP00000008196	ENSPPYP00000009634	TAOK2 isoform 1.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.953
TAOK2	TAOK3	ENSPPYP00000008196	ENSPPYP00000024760	TAOK2 isoform 1.	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	0.917
TAOK3	FLNC	ENSPPYP00000024760	ENSPPYP00000020178	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	FLNC isoform 2.	0.635
TAOK3	IGFBP3	ENSPPYP00000024760	ENSPPYP00000019699	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	Insulin like growth factor binding protein 3.	0.473
TAOK3	IGFBP5	ENSPPYP00000024760	ENSPPYP00000014701	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	IGFBP5 isoform 1.	0.421
TAOK3	MAP2K3	ENSPPYP00000024760	ENSPPYP00000009080	Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...]	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.918

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