| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKS3 | ANKS6 | ENSP00000304586 | ENSP00000297837 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | 0.986 |
| ANKS3 | E4F1 | ENSP00000304586 | ENSP00000301727 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | 0.562 |
| ANKS3 | LRRC45 | ENSP00000304586 | ENSP00000306760 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.695 |
| ANKS3 | NEK6 | ENSP00000304586 | ENSP00000362702 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | 0.904 |
| ANKS3 | NEK7 | ENSP00000304586 | ENSP00000356355 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. | 0.988 |
| ANKS3 | NEK8 | ENSP00000304586 | ENSP00000268766 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.939 |
| ANKS3 | NEK9 | ENSP00000304586 | ENSP00000238616 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively. | 0.606 |
| ANKS3 | NPHP1 | ENSP00000304586 | ENSP00000313169 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina dev [...] | 0.624 |
| ANKS3 | ZNF214 | ENSP00000304586 | ENSP00000278314 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Zinc finger protein 214; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.566 |
| ANKS3 | ZNF556 | ENSP00000304586 | ENSP00000302603 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | Zinc finger protein 556; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.577 |
| ANKS6 | ANKS3 | ENSP00000297837 | ENSP00000304586 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | 0.986 |
| ANKS6 | NEK6 | ENSP00000297837 | ENSP00000362702 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | 0.894 |
| ANKS6 | NEK7 | ENSP00000297837 | ENSP00000356355 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. | 0.992 |
| ANKS6 | NEK8 | ENSP00000297837 | ENSP00000268766 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.985 |
| ANKS6 | NEK9 | ENSP00000297837 | ENSP00000238616 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively. | 0.718 |
| ANKS6 | NPHP1 | ENSP00000297837 | ENSP00000313169 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina dev [...] | 0.693 |
| E4F1 | ANKS3 | ENSP00000301727 | ENSP00000304586 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | 0.562 |
| LRRC45 | ANKS3 | ENSP00000306760 | ENSP00000304586 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | 0.695 |
| NEK6 | ANKS3 | ENSP00000362702 | ENSP00000304586 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. | 0.904 |
| NEK6 | ANKS6 | ENSP00000362702 | ENSP00000297837 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. | 0.894 |
