node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAU | IFRD1 | ENSP00000431822 | ENSP00000384477 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | 0.967 |
FAU | RPL18A | ENSP00000431822 | ENSP00000222247 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. | 0.999 |
FAU | RPL31 | ENSP00000431822 | ENSP00000386717 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Ribosomal protein L31. | 0.999 |
FAU | RPL36 | ENSP00000431822 | ENSP00000464342 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L36; Component of the large ribosomal subunit. | 0.999 |
FAU | RPL38 | ENSP00000431822 | ENSP00000309830 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. | 0.999 |
FAU | RPL8 | ENSP00000431822 | ENSP00000262584 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L8; Component of the large ribosomal subunit. | 0.999 |
FAU | RPS21 | ENSP00000431822 | ENSP00000345957 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. | 0.999 |
FAU | RPS7 | ENSP00000431822 | ENSP00000495273 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 40S ribosomal protein S7; Required for rRNA maturation. | 0.999 |
HDAC1 | IFRD1 | ENSP00000362649 | ENSP00000384477 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | 0.837 |
HDAC1 | SIN3B | ENSP00000362649 | ENSP00000369131 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. | 0.999 |
IFRD1 | FAU | ENSP00000384477 | ENSP00000431822 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.967 |
IFRD1 | HDAC1 | ENSP00000384477 | ENSP00000362649 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.837 |
IFRD1 | RPL18A | ENSP00000384477 | ENSP00000222247 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. | 0.770 |
IFRD1 | RPL31 | ENSP00000384477 | ENSP00000386717 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Ribosomal protein L31. | 0.779 |
IFRD1 | RPL36 | ENSP00000384477 | ENSP00000464342 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | 60S ribosomal protein L36; Component of the large ribosomal subunit. | 0.775 |
IFRD1 | RPL38 | ENSP00000384477 | ENSP00000309830 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. | 0.767 |
IFRD1 | RPL8 | ENSP00000384477 | ENSP00000262584 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | 60S ribosomal protein L8; Component of the large ribosomal subunit. | 0.769 |
IFRD1 | RPS21 | ENSP00000384477 | ENSP00000345957 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. | 0.773 |
IFRD1 | RPS7 | ENSP00000384477 | ENSP00000495273 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | 40S ribosomal protein S7; Required for rRNA maturation. | 0.768 |
IFRD1 | SIN3B | ENSP00000384477 | ENSP00000369131 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. | Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. | 0.769 |