node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | CEACAM5 | ENSP00000295463 | ENSP00000221992 | Alkaline phosphatase, intestinal. | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family. | 0.479 |
ALPI | CEACAM7 | ENSP00000295463 | ENSP00000006724 | Alkaline phosphatase, intestinal. | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | 0.459 |
CEACAM5 | ALPI | ENSP00000221992 | ENSP00000295463 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family. | Alkaline phosphatase, intestinal. | 0.479 |
CEACAM5 | CEACAM7 | ENSP00000221992 | ENSP00000006724 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family. | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | 0.658 |
CEACAM7 | ALPI | ENSP00000006724 | ENSP00000295463 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Alkaline phosphatase, intestinal. | 0.459 |
CEACAM7 | CEACAM5 | ENSP00000006724 | ENSP00000221992 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family. | 0.658 |
CEACAM7 | CLCA4 | ENSP00000006724 | ENSP00000359594 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance. | 0.450 |
CEACAM7 | CYP2A13 | ENSP00000006724 | ENSP00000332679 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. | 0.555 |
CEACAM7 | CYP2A6 | ENSP00000006724 | ENSP00000301141 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Cytochrome P450 2A6; Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo- monooxygenase. Possesses low phenacetin O-deethylation activity. | 0.481 |
CEACAM7 | CYP2A7 | ENSP00000006724 | ENSP00000301146 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Cytochrome P450 2A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.535 |
CEACAM7 | MS4A12 | ENSP00000006724 | ENSP00000016913 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. | 0.519 |
CEACAM7 | NXPE4 | ENSP00000006724 | ENSP00000364627 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family. | 0.523 |
CEACAM7 | SLC26A3 | ENSP00000006724 | ENSP00000345873 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. | 0.455 |
CEACAM7 | ZNF574 | ENSP00000006724 | ENSP00000222339 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.550 |
CLCA4 | CEACAM7 | ENSP00000359594 | ENSP00000006724 | Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance. | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | 0.450 |
CLCA4 | MS4A12 | ENSP00000359594 | ENSP00000016913 | Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance. | Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. | 0.706 |
CLCA4 | SLC26A3 | ENSP00000359594 | ENSP00000345873 | Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance. | Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. | 0.553 |
CYP2A13 | CEACAM7 | ENSP00000332679 | ENSP00000006724 | Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | 0.555 |
CYP2A13 | CYP2A6 | ENSP00000332679 | ENSP00000301141 | Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. | Cytochrome P450 2A6; Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo- monooxygenase. Possesses low phenacetin O-deethylation activity. | 0.911 |
CYP2A13 | CYP2A7 | ENSP00000332679 | ENSP00000301146 | Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. | Cytochrome P450 2A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.400 |