STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT33AKeratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family. (404 aa)    
Predicted Functional Partners:
KRT31
Keratin, type I cuticular Ha1; Keratin 31.
  
 
0.776
KRT33B
Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
  
 
0.711
KRT34
Keratin, type I cuticular Ha4; Keratin 34.
  
 
0.707
KRT35
Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.
  
 
0.656
KRT27
Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
  
0.624
KRT4
Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family.
  
 
0.614
KRT20
Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
  
 
0.571
KRT18
Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
     
0.563
MT1E
Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.
      
 0.557
MT1A
Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.
      
 0.550
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.