node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DIPK1A | FAM136A | ENSP00000359333 | ENSP00000397269 | Divergent protein kinase domain 1A. | Protein FAM136A; Family with sequence similarity 136 member A. | 0.596 |
DIPK1A | PPP6R2 | ENSP00000359333 | ENSP00000478417 | Divergent protein kinase domain 1A. | Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family. | 0.493 |
DTNA | FAM136A | ENSP00000470152 | ENSP00000397269 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. | Protein FAM136A; Family with sequence similarity 136 member A. | 0.726 |
FAM136A | DIPK1A | ENSP00000397269 | ENSP00000359333 | Protein FAM136A; Family with sequence similarity 136 member A. | Divergent protein kinase domain 1A. | 0.596 |
FAM136A | DTNA | ENSP00000397269 | ENSP00000470152 | Protein FAM136A; Family with sequence similarity 136 member A. | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. | 0.726 |
FAM136A | HCCS | ENSP00000397269 | ENSP00000370139 | Protein FAM136A; Family with sequence similarity 136 member A. | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.438 |
FAM136A | OTOG | ENSP00000397269 | ENSP00000382323 | Protein FAM136A; Family with sequence similarity 136 member A. | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | 0.454 |
FAM136A | PHB2 | ENSP00000397269 | ENSP00000441875 | Protein FAM136A; Family with sequence similarity 136 member A. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. | 0.452 |
FAM136A | PPP6R2 | ENSP00000397269 | ENSP00000478417 | Protein FAM136A; Family with sequence similarity 136 member A. | Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family. | 0.481 |
FAM136A | PRKCB | ENSP00000397269 | ENSP00000496129 | Protein FAM136A; Family with sequence similarity 136 member A. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.474 |
FAM136A | RBFOX2 | ENSP00000397269 | ENSP00000413035 | Protein FAM136A; Family with sequence similarity 136 member A. | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. | 0.447 |
FAM136A | SEMA3D | ENSP00000397269 | ENSP00000284136 | Protein FAM136A; Family with sequence similarity 136 member A. | Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). | 0.613 |
FAM136A | WDR55 | ENSP00000397269 | ENSP00000351100 | Protein FAM136A; Family with sequence similarity 136 member A. | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). | 0.426 |
HCCS | FAM136A | ENSP00000370139 | ENSP00000397269 | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Protein FAM136A; Family with sequence similarity 136 member A. | 0.438 |
HCCS | PHB2 | ENSP00000370139 | ENSP00000441875 | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. | 0.479 |
OTOG | FAM136A | ENSP00000382323 | ENSP00000397269 | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | Protein FAM136A; Family with sequence similarity 136 member A. | 0.454 |
PHB2 | FAM136A | ENSP00000441875 | ENSP00000397269 | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. | Protein FAM136A; Family with sequence similarity 136 member A. | 0.452 |
PHB2 | HCCS | ENSP00000441875 | ENSP00000370139 | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.479 |
PPP6R2 | DIPK1A | ENSP00000478417 | ENSP00000359333 | Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family. | Divergent protein kinase domain 1A. | 0.493 |
PPP6R2 | FAM136A | ENSP00000478417 | ENSP00000397269 | Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family. | Protein FAM136A; Family with sequence similarity 136 member A. | 0.481 |