| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DGKH | RIPOR3 | ENSP00000337572 | ENSP00000045083 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. | RIPOR family member 3. | 0.466 |
| FAU | RIPOR3 | ENSP00000431822 | ENSP00000045083 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | RIPOR family member 3. | 0.535 |
| MTMR9 | RIPOR3 | ENSP00000221086 | ENSP00000045083 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | RIPOR family member 3. | 0.465 |
| RHOA | RHOC | ENSP00000400175 | ENSP00000285735 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | 0.999 |
| RHOA | RIPOR3 | ENSP00000400175 | ENSP00000045083 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | RIPOR family member 3. | 0.618 |
| RHOC | RHOA | ENSP00000285735 | ENSP00000400175 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.999 |
| RHOC | RIPOR3 | ENSP00000285735 | ENSP00000045083 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | RIPOR family member 3. | 0.578 |
| RIPOR3 | DGKH | ENSP00000045083 | ENSP00000337572 | RIPOR family member 3. | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. | 0.466 |
| RIPOR3 | FAU | ENSP00000045083 | ENSP00000431822 | RIPOR family member 3. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.535 |
| RIPOR3 | MTMR9 | ENSP00000045083 | ENSP00000221086 | RIPOR family member 3. | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | 0.465 |
| RIPOR3 | RHOA | ENSP00000045083 | ENSP00000400175 | RIPOR family member 3. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.618 |
| RIPOR3 | RHOC | ENSP00000045083 | ENSP00000285735 | RIPOR family member 3. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | 0.578 |
| RIPOR3 | SCML4 | ENSP00000045083 | ENSP00000358016 | RIPOR family member 3. | Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). | 0.408 |
| RIPOR3 | SEMA6B | ENSP00000045083 | ENSP00000467290 | RIPOR family member 3. | Semaphorin-6B; May play a role in both peripheral and central nervous system development. | 0.457 |
| RIPOR3 | SLC9A3R1 | ENSP00000045083 | ENSP00000262613 | RIPOR family member 3. | Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of [...] | 0.591 |
| RIPOR3 | SUSD1 | ENSP00000045083 | ENSP00000363382 | RIPOR family member 3. | Sushi domain containing 1. | 0.494 |
| RIPOR3 | TMEM72 | ENSP00000045083 | ENSP00000374234 | RIPOR family member 3. | Transmembrane protein 72. | 0.408 |
| SCML4 | RIPOR3 | ENSP00000358016 | ENSP00000045083 | Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). | RIPOR family member 3. | 0.408 |
| SEMA6B | RIPOR3 | ENSP00000467290 | ENSP00000045083 | Semaphorin-6B; May play a role in both peripheral and central nervous system development. | RIPOR family member 3. | 0.457 |
| SLC9A3R1 | RIPOR3 | ENSP00000262613 | ENSP00000045083 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of [...] | RIPOR family member 3. | 0.591 |
