node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGL | AMY1B | ENSP00000294724 | ENSP00000330484 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.963 |
AGL | AMY2A | ENSP00000294724 | ENSP00000481450 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Pancreatic alpha-amylase; Amylase alpha 2A. | 0.961 |
AGL | AMY2B | ENSP00000294724 | ENSP00000354610 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.962 |
AGL | GBE1 | ENSP00000294724 | ENSP00000410833 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.993 |
AGL | MGAM | ENSP00000294724 | ENSP00000447378 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. | 0.960 |
AGL | PGM2 | ENSP00000294724 | ENSP00000371393 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. May also catalyze the interconversion of glucose-1- phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity; Belongs to the phosphohexose mutase family. | 0.929 |
AGL | PYGB | ENSP00000294724 | ENSP00000216962 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.999 |
AGL | PYGM | ENSP00000294724 | ENSP00000164139 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.997 |
AGL | UGP2 | ENSP00000294724 | ENSP00000338703 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family. | 0.967 |
AMY1B | AGL | ENSP00000330484 | ENSP00000294724 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 0.963 |
AMY1B | AMY2A | ENSP00000330484 | ENSP00000481450 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Pancreatic alpha-amylase; Amylase alpha 2A. | 0.901 |
AMY1B | AMY2B | ENSP00000330484 | ENSP00000354610 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.915 |
AMY1B | GBE1 | ENSP00000330484 | ENSP00000410833 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.977 |
AMY1B | MGAM | ENSP00000330484 | ENSP00000447378 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. | 0.998 |
AMY1B | PYGB | ENSP00000330484 | ENSP00000216962 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.972 |
AMY1B | PYGM | ENSP00000330484 | ENSP00000164139 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.970 |
AMY1B | RIPK3 | ENSP00000330484 | ENSP00000216274 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. Belongs to the protein kinase superfamily. TKL Ser/T [...] | 0.430 |
AMY2A | AGL | ENSP00000481450 | ENSP00000294724 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 0.961 |
AMY2A | AMY1B | ENSP00000481450 | ENSP00000330484 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.901 |
AMY2A | AMY2B | ENSP00000481450 | ENSP00000354610 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.960 |