node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA12 | CA14 | ENSP00000178638 | ENSP00000358107 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | 0.569 |
CA12 | CA4 | ENSP00000178638 | ENSP00000300900 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Belongs to the alpha-carbonic anhydrase family. | 0.640 |
CA12 | CA9 | ENSP00000178638 | ENSP00000367608 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. | 0.739 |
CA12 | CYP24A1 | ENSP00000178638 | ENSP00000216862 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidati [...] | 0.806 |
CA12 | RPF2 | ENSP00000178638 | ENSP00000402338 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.561 |
CA12 | SLC2A1 | ENSP00000178638 | ENSP00000416293 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. | 0.577 |
CA12 | SLC4A2 | ENSP00000178638 | ENSP00000419412 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. | 0.649 |
CA12 | SLC4A4 | ENSP00000178638 | ENSP00000393557 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Belongs to the anion exchanger (TC 2.A.31) family. | 0.553 |
CA12 | SLC9A1 | ENSP00000178638 | ENSP00000263980 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.649 |
CA12 | VHL | ENSP00000178638 | ENSP00000256474 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2; Belongs to the VHL family. | 0.556 |
CA14 | CA12 | ENSP00000358107 | ENSP00000178638 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | 0.569 |
CA14 | CA4 | ENSP00000358107 | ENSP00000300900 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Belongs to the alpha-carbonic anhydrase family. | 0.662 |
CA14 | CA9 | ENSP00000358107 | ENSP00000367608 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. | 0.615 |
CA14 | CYP24A1 | ENSP00000358107 | ENSP00000216862 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidati [...] | 0.850 |
CA14 | RPF2 | ENSP00000358107 | ENSP00000402338 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.568 |
CA14 | SLC4A2 | ENSP00000358107 | ENSP00000419412 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. | 0.558 |
CA14 | SLC4A4 | ENSP00000358107 | ENSP00000393557 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Belongs to the anion exchanger (TC 2.A.31) family. | 0.568 |
CA14 | SLC9A1 | ENSP00000358107 | ENSP00000263980 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.405 |
CA4 | CA12 | ENSP00000300900 | ENSP00000178638 | Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family. | 0.640 |
CA4 | CA14 | ENSP00000300900 | ENSP00000358107 | Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 14; Reversible hydration of carbon dioxide. | 0.662 |