node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMIGO3 | TMEM131 | ENSP00000323096 | ENSP00000186436 | Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.535 |
AMIGO3 | ZDHHC14 | ENSP00000323096 | ENSP00000352821 | Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). | Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type palmitoyltransferase 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.471 |
CNOT6L | TMEM131 | ENSP00000424896 | ENSP00000186436 | CCR4-NOT transcription complex subunit 6-like; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.513 |
ERICH1 | TMEM131 | ENSP00000262109 | ENSP00000186436 | Glutamate-rich protein 1; Glutamate rich 1. | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.488 |
MIA3 | TMEM131 | ENSP00000340900 | ENSP00000186436 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.476 |
RALGAPB | TMEM131 | ENSP00000262879 | ENSP00000186436 | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.702 |
RALGAPB | TRAPPC8 | ENSP00000262879 | ENSP00000283351 | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. | Trafficking protein particle complex subunit 8; Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy ; Belongs to the TRS85 family. | 0.550 |
RALGAPB | UBP1 | ENSP00000262879 | ENSP00000283629 | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. | Upstream-binding protein 1; Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA- box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box; Belongs [...] | 0.619 |
SH3BP2 | TMEM131 | ENSP00000424846 | ENSP00000186436 | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.498 |
ST20 | TMEM131 | ENSP00000453502 | ENSP00000186436 | Suppressor of tumorigenicity 20 protein; May act as a tumor suppressor. Promotes apoptosis of cancer cells. | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.446 |
TMEM131 | AMIGO3 | ENSP00000186436 | ENSP00000323096 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). | 0.535 |
TMEM131 | CNOT6L | ENSP00000186436 | ENSP00000424896 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | CCR4-NOT transcription complex subunit 6-like; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.513 |
TMEM131 | ERICH1 | ENSP00000186436 | ENSP00000262109 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Glutamate-rich protein 1; Glutamate rich 1. | 0.488 |
TMEM131 | MIA3 | ENSP00000186436 | ENSP00000340900 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | 0.476 |
TMEM131 | RALGAPB | ENSP00000186436 | ENSP00000262879 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. | 0.702 |
TMEM131 | SH3BP2 | ENSP00000186436 | ENSP00000424846 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | 0.498 |
TMEM131 | ST20 | ENSP00000186436 | ENSP00000453502 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Suppressor of tumorigenicity 20 protein; May act as a tumor suppressor. Promotes apoptosis of cancer cells. | 0.446 |
TMEM131 | TRAPPC8 | ENSP00000186436 | ENSP00000283351 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Trafficking protein particle complex subunit 8; Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy ; Belongs to the TRS85 family. | 0.614 |
TMEM131 | UBP1 | ENSP00000186436 | ENSP00000283629 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Upstream-binding protein 1; Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA- box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box; Belongs [...] | 0.540 |
TMEM131 | ZDHHC14 | ENSP00000186436 | ENSP00000352821 | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type palmitoyltransferase 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.486 |