node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEST1 | CERKL | ENSP00000399709 | ENSP00000341159 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | 0.705 |
BEST1 | EYS | ENSP00000399709 | ENSP00000359655 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity); Belongs to the EYS family. | 0.745 |
BEST1 | IMPG2 | ENSP00000399709 | ENSP00000193391 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. | 0.775 |
BEST1 | PCARE | ENSP00000399709 | ENSP00000332809 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Photoreceptor cilium actin regulator; Plays an essential role for normal photoreceptor cell maintenance and vision. | 0.687 |
BEST1 | PDE6A | ENSP00000399709 | ENSP00000255266 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.703 |
BEST1 | PDE6G | ENSP00000399709 | ENSP00000328412 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones. | 0.668 |
BEST1 | PRCD | ENSP00000399709 | ENSP00000467661 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Photoreceptor disk component PRCD; Involved in vision; Belongs to the PRCD family. | 0.728 |
BEST1 | PRPH2 | ENSP00000399709 | ENSP00000230381 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.868 |
BEST1 | RDH12 | ENSP00000399709 | ENSP00000449079 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Retinol dehydrogenase 12; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards stero [...] | 0.708 |
BEST1 | ZNF513 | ENSP00000399709 | ENSP00000318373 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance. | 0.685 |
CERKL | BEST1 | ENSP00000341159 | ENSP00000399709 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.705 |
CERKL | EYS | ENSP00000341159 | ENSP00000359655 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity); Belongs to the EYS family. | 0.857 |
CERKL | IMPG2 | ENSP00000341159 | ENSP00000193391 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. | 0.787 |
CERKL | PCARE | ENSP00000341159 | ENSP00000332809 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Photoreceptor cilium actin regulator; Plays an essential role for normal photoreceptor cell maintenance and vision. | 0.805 |
CERKL | PDE6A | ENSP00000341159 | ENSP00000255266 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.825 |
CERKL | PDE6G | ENSP00000341159 | ENSP00000328412 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones. | 0.739 |
CERKL | PRCD | ENSP00000341159 | ENSP00000467661 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Photoreceptor disk component PRCD; Involved in vision; Belongs to the PRCD family. | 0.800 |
CERKL | PRPH2 | ENSP00000341159 | ENSP00000230381 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.768 |
CERKL | RDH12 | ENSP00000341159 | ENSP00000449079 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Retinol dehydrogenase 12; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards stero [...] | 0.828 |
CERKL | ZNF513 | ENSP00000341159 | ENSP00000318373 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance. | 0.784 |