node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH16A1 | SPG21 | ENSP00000293350 | ENSP00000204566 | Aldehyde dehydrogenase 16 family member A1. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.952 |
AP5Z1 | GJC2 | ENSP00000497815 | ENSP00000355675 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | 0.839 |
AP5Z1 | NIPA1 | ENSP00000497815 | ENSP00000337452 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family. | 0.592 |
AP5Z1 | PNPLA6 | ENSP00000497815 | ENSP00000407509 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. | 0.880 |
AP5Z1 | SPART | ENSP00000497815 | ENSP00000414147 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.775 |
AP5Z1 | SPG11 | ENSP00000497815 | ENSP00000261866 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.996 |
AP5Z1 | SPG21 | ENSP00000497815 | ENSP00000204566 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.868 |
AP5Z1 | SPG7 | ENSP00000497815 | ENSP00000495795 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.822 |
AP5Z1 | ZFYVE26 | ENSP00000497815 | ENSP00000251119 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. | 0.992 |
GJC2 | AP5Z1 | ENSP00000355675 | ENSP00000497815 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | 0.839 |
GJC2 | NIPA1 | ENSP00000355675 | ENSP00000337452 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family. | 0.481 |
GJC2 | PNPLA6 | ENSP00000355675 | ENSP00000407509 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. | 0.866 |
GJC2 | SPART | ENSP00000355675 | ENSP00000414147 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.760 |
GJC2 | SPG11 | ENSP00000355675 | ENSP00000261866 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.779 |
GJC2 | SPG21 | ENSP00000355675 | ENSP00000204566 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.820 |
GJC2 | SPG7 | ENSP00000355675 | ENSP00000495795 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.786 |
GJC2 | ZFYVE26 | ENSP00000355675 | ENSP00000251119 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. | 0.513 |
NIPA1 | AP5Z1 | ENSP00000337452 | ENSP00000497815 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | 0.592 |
NIPA1 | GJC2 | ENSP00000337452 | ENSP00000355675 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family. | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. | 0.481 |
NIPA1 | PNPLA6 | ENSP00000337452 | ENSP00000407509 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. | 0.577 |