Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACLY | CS | ENSP00000466259 | ENSP00000342056 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.998 |
| ACLY | SLC25A1 | ENSP00000466259 | ENSP00000215882 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.832 |
| C15orf40 | CS | ENSP00000403987 | ENSP00000342056 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.798 |
| C15orf40 | DRG1 | ENSP00000403987 | ENSP00000329715 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.802 |
| C15orf40 | GRN | ENSP00000403987 | ENSP00000053867 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelia [...] | 0.797 |
| C15orf40 | POLE2 | ENSP00000403987 | ENSP00000216367 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.798 |
| C15orf40 | SLC25A1 | ENSP00000403987 | ENSP00000215882 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.798 |
| CLTCL1 | DGCR2 | ENSP00000441158 | ENSP00000263196 | Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network (By similarity). | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | 0.727 |
| CLTCL1 | ESS2 | ENSP00000441158 | ENSP00000252137 | Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network (By similarity). | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.706 |
| CLTCL1 | SLC25A1 | ENSP00000441158 | ENSP00000215882 | Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network (By similarity). | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.853 |
| CS | ACLY | ENSP00000342056 | ENSP00000466259 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.998 |
| CS | C15orf40 | ENSP00000342056 | ENSP00000403987 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.798 |
| CS | DRG1 | ENSP00000342056 | ENSP00000329715 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.805 |
| CS | GRN | ENSP00000342056 | ENSP00000053867 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelia [...] | 0.807 |
| CS | POLE2 | ENSP00000342056 | ENSP00000216367 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.800 |
| CS | SLC25A1 | ENSP00000342056 | ENSP00000215882 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.964 |
| DGCR2 | CLTCL1 | ENSP00000263196 | ENSP00000441158 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network (By similarity). | 0.727 |
| DGCR2 | ESS2 | ENSP00000263196 | ENSP00000252137 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.943 |
| DGCR2 | MRPL40 | ENSP00000263196 | ENSP00000333401 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. | 0.608 |
| DGCR2 | SLC25A1 | ENSP00000263196 | ENSP00000215882 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.808 |
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