C22orf31 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C20orf144	C22orf31	ENSP00000364370	ENSP00000216071	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	0.549
C20orf144	CXorf49	ENSP00000364370	ENSP00000480355	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	0.567
C20orf144	CXorf49B	ENSP00000364370	ENSP00000482270	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	Chromosome X open reading frame 49B.	0.569
C22orf31	C20orf144	ENSP00000216071	ENSP00000364370	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.549
C22orf31	CXorf49	ENSP00000216071	ENSP00000480355	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	0.537
C22orf31	CXorf49B	ENSP00000216071	ENSP00000482270	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Chromosome X open reading frame 49B.	0.540
C22orf31	FBXO7	ENSP00000216071	ENSP00000266087	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.	0.457
C22orf31	HDAC1	ENSP00000216071	ENSP00000362649	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	0.563
C22orf31	HDAC2	ENSP00000216071	ENSP00000430432	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S- phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed [...]	0.808
C22orf31	KLHL20	ENSP00000216071	ENSP00000209884	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...]	0.488
C22orf31	LACRT	ENSP00000216071	ENSP00000257867	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	0.667
C22orf31	LPCAT2	ENSP00000216071	ENSP00000262134	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, ac [...]	0.469
C22orf31	TMED10	ENSP00000216071	ENSP00000303145	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...]	0.468
CXorf49	C20orf144	ENSP00000480355	ENSP00000364370	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.567
CXorf49	C22orf31	ENSP00000480355	ENSP00000216071	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	0.537
CXorf49	CXorf49B	ENSP00000480355	ENSP00000482270	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	Chromosome X open reading frame 49B.	0.978
CXorf49B	C20orf144	ENSP00000482270	ENSP00000364370	Chromosome X open reading frame 49B.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.569
CXorf49B	C22orf31	ENSP00000482270	ENSP00000216071	Chromosome X open reading frame 49B.	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	0.540
CXorf49B	CXorf49	ENSP00000482270	ENSP00000480355	Chromosome X open reading frame 49B.	Uncharacterized protein CXorf49; Chromosome X open reading frame 49.	0.978
FBXO7	C22orf31	ENSP00000266087	ENSP00000216071	F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	0.457