STRINGSTRING
PVALB protein (human) - STRING interaction network
"PVALB" - Parvalbumin alpha in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing (110 aa)    
Predicted Functional Partners:
CALB1
Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing (261 aa)
     
   
  0.945
CALB2
Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing (271 aa)
     
   
  0.944
SST
Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands (116 aa)
     
   
  0.923
GAD1
Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family (594 aa)
     
 
  0.901
CCK
Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands (115 aa)
     
   
  0.870
GAD2
Glutamate decarboxylase 2; Catalyzes the production of GABA (585 aa)
     
 
  0.865
NPY
Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family (97 aa)
     
   
  0.850
SDF4
45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family (362 aa)
           
  0.831
GRIN1
Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily (943 aa)
     
 
  0.815
RBFOX3
RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD); RNA binding motif containing (312 aa)
     
   
  0.810
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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