node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCHE | COCH | ENSP00000264381 | ENSP00000216361 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.660 |
CALB1 | COCH | ENSP00000265431 | ENSP00000216361 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.675 |
CALB1 | TECTB | ENSP00000265431 | ENSP00000494896 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.666 |
COCH | BCHE | ENSP00000216361 | ENSP00000264381 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family. | 0.660 |
COCH | CALB1 | ENSP00000216361 | ENSP00000265431 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | 0.675 |
COCH | COL2A1 | ENSP00000216361 | ENSP00000369889 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.699 |
COCH | FAU | ENSP00000216361 | ENSP00000431822 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.830 |
COCH | SLC22A17 | ENSP00000216361 | ENSP00000380437 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.831 |
COCH | SLC44A2 | ENSP00000216361 | ENSP00000466664 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Choline transporter-like protein 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Belongs to the CTL (choline transporter-like) family. | 0.819 |
COCH | STXBP6 | ENSP00000216361 | ENSP00000324302 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. | 0.826 |
COCH | TECTA | ENSP00000216361 | ENSP00000376543 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.782 |
COCH | TECTB | ENSP00000216361 | ENSP00000494896 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.902 |
COCH | VIT | ENSP00000216361 | ENSP00000368544 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Vitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. | 0.649 |
COL2A1 | COCH | ENSP00000369889 | ENSP00000216361 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.699 |
COL2A1 | TECTB | ENSP00000369889 | ENSP00000494896 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.485 |
FAU | COCH | ENSP00000431822 | ENSP00000216361 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.830 |
FAU | TECTA | ENSP00000431822 | ENSP00000376543 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.867 |
FAU | VIT | ENSP00000431822 | ENSP00000368544 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Vitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. | 0.816 |
SLC22A17 | COCH | ENSP00000380437 | ENSP00000216361 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.831 |
SLC22A17 | STXBP6 | ENSP00000380437 | ENSP00000324302 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. | 0.850 |