node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | NOXRED1 | ENSP00000360268 | ENSP00000370215 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.742 |
ALDH18A1 | OAT | ENSP00000360268 | ENSP00000357838 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | 0.998 |
ALDH18A1 | TMED8 | ENSP00000360268 | ENSP00000216468 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.710 |
C14orf178 | NOXRED1 | ENSP00000348145 | ENSP00000370215 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.634 |
C14orf178 | SAMD15 | ENSP00000348145 | ENSP00000216471 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | Sterile alpha motif domain containing 15. | 0.659 |
C14orf178 | TMED8 | ENSP00000348145 | ENSP00000216468 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.577 |
GSTZ1 | TMED8 | ENSP00000451976 | ENSP00000216468 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.432 |
HLCS | TMED8 | ENSP00000382071 | ENSP00000216468 | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.452 |
KCNJ10 | TMED8 | ENSP00000495557 | ENSP00000216468 | ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellu [...] | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.420 |
L3HYPDH | NOXRED1 | ENSP00000247194 | ENSP00000370215 | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.549 |
L3HYPDH | TMED8 | ENSP00000247194 | ENSP00000216468 | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.550 |
NOXRED1 | ALDH18A1 | ENSP00000370215 | ENSP00000360268 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | 0.742 |
NOXRED1 | C14orf178 | ENSP00000370215 | ENSP00000348145 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | 0.634 |
NOXRED1 | L3HYPDH | ENSP00000370215 | ENSP00000247194 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | 0.549 |
NOXRED1 | OAT | ENSP00000370215 | ENSP00000357838 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | 0.481 |
NOXRED1 | SAMD15 | ENSP00000370215 | ENSP00000216471 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Sterile alpha motif domain containing 15. | 0.513 |
NOXRED1 | TMED8 | ENSP00000370215 | ENSP00000216468 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.636 |
OAT | ALDH18A1 | ENSP00000357838 | ENSP00000360268 | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | 0.998 |
OAT | NOXRED1 | ENSP00000357838 | ENSP00000370215 | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.481 |
OAT | TMED8 | ENSP00000357838 | ENSP00000216468 | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.481 |