node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPG1 | DHRS7 | ENSP00000325002 | ENSP00000216500 | Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | 0.446 |
DHRS1 | DHRS7 | ENSP00000380027 | ENSP00000216500 | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | 0.474 |
DHRS1 | FDX1 | ENSP00000380027 | ENSP00000260270 | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | 0.464 |
DHRS1 | FDX2 | ENSP00000380027 | ENSP00000377311 | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.463 |
DHRS1 | OXSM | ENSP00000380027 | ENSP00000280701 | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.469 |
DHRS7 | COPG1 | ENSP00000216500 | ENSP00000325002 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | 0.446 |
DHRS7 | DHRS1 | ENSP00000216500 | ENSP00000380027 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.474 |
DHRS7 | ESYT1 | ENSP00000216500 | ENSP00000267113 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family. | 0.463 |
DHRS7 | FDX1 | ENSP00000216500 | ENSP00000260270 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | 0.474 |
DHRS7 | FDX2 | ENSP00000216500 | ENSP00000377311 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.463 |
DHRS7 | HAO2 | ENSP00000216500 | ENSP00000354314 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.470 |
DHRS7 | HECTD3 | ENSP00000216500 | ENSP00000361245 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). | 0.471 |
DHRS7 | OXSM | ENSP00000216500 | ENSP00000280701 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.459 |
DHRS7 | TMEM126A | ENSP00000216500 | ENSP00000306887 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Transmembrane protein 126A; Belongs to the TMEM126 family. | 0.552 |
DHRS7 | TMEM38A | ENSP00000216500 | ENSP00000187762 | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.523 |
ESYT1 | DHRS7 | ENSP00000267113 | ENSP00000216500 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family. | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | 0.463 |
FDX1 | DHRS1 | ENSP00000260270 | ENSP00000380027 | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.464 |
FDX1 | DHRS7 | ENSP00000260270 | ENSP00000216500 | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7. | 0.474 |
FDX1 | FDX2 | ENSP00000260270 | ENSP00000377311 | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.856 |
FDX2 | DHRS1 | ENSP00000377311 | ENSP00000380027 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.463 |