node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCLC | GCLM | ENSP00000497574 | ENSP00000359258 | Glutamate-cysteine ligase catalytic subunit. | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.999 |
GCLC | GGT1 | ENSP00000497574 | ENSP00000248923 | Glutamate-cysteine ligase catalytic subunit. | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.944 |
GCLC | GGT5 | ENSP00000497574 | ENSP00000381340 | Glutamate-cysteine ligase catalytic subunit. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.923 |
GCLC | GGT6 | ENSP00000497574 | ENSP00000370962 | Glutamate-cysteine ligase catalytic subunit. | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.942 |
GCLC | GGT7 | ENSP00000497574 | ENSP00000338964 | Glutamate-cysteine ligase catalytic subunit. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.925 |
GCLC | GPX3 | ENSP00000497574 | ENSP00000373477 | Glutamate-cysteine ligase catalytic subunit. | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | 0.705 |
GCLC | GSR | ENSP00000497574 | ENSP00000221130 | Glutamate-cysteine ligase catalytic subunit. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | 0.874 |
GCLC | GSS | ENSP00000497574 | ENSP00000495750 | Glutamate-cysteine ligase catalytic subunit. | Glutathione synthetase. | 0.995 |
GCLC | GSTO1 | ENSP00000497574 | ENSP00000358727 | Glutamate-cysteine ligase catalytic subunit. | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. | 0.531 |
GCLC | HPGDS | ENSP00000497574 | ENSP00000295256 | Glutamate-cysteine ligase catalytic subunit. | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family. | 0.665 |
GCLM | GCLC | ENSP00000359258 | ENSP00000497574 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutamate-cysteine ligase catalytic subunit. | 0.999 |
GCLM | GGT1 | ENSP00000359258 | ENSP00000248923 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.935 |
GCLM | GGT5 | ENSP00000359258 | ENSP00000381340 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.918 |
GCLM | GGT6 | ENSP00000359258 | ENSP00000370962 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.919 |
GCLM | GGT7 | ENSP00000359258 | ENSP00000338964 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.915 |
GCLM | GPX3 | ENSP00000359258 | ENSP00000373477 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | 0.654 |
GCLM | GSR | ENSP00000359258 | ENSP00000221130 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | 0.799 |
GCLM | GSS | ENSP00000359258 | ENSP00000495750 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione synthetase. | 0.989 |
GCLM | GSTO1 | ENSP00000359258 | ENSP00000358727 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. | 0.444 |
GCLM | HPGDS | ENSP00000359258 | ENSP00000295256 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family. | 0.562 |