node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMY1B | CST1 | ENSP00000330484 | ENSP00000305731 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | 0.439 |
AMY1B | CST4 | ENSP00000330484 | ENSP00000217423 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | 0.764 |
AMY1B | LCN1 | ENSP00000330484 | ENSP00000263598 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family. | 0.535 |
AMY1B | MUC5B | ENSP00000330484 | ENSP00000436812 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Mucin-5B; Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. | 0.714 |
AMY1B | MUC7 | ENSP00000330484 | ENSP00000407422 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. | 0.500 |
AMY1B | STATH | ENSP00000330484 | ENSP00000246895 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface. | 0.507 |
CST1 | AMY1B | ENSP00000305731 | ENSP00000330484 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.439 |
CST1 | CST2 | ENSP00000305731 | ENSP00000307540 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Cystatin-SA; Thiol protease inhibitor. | 0.999 |
CST1 | CST4 | ENSP00000305731 | ENSP00000217423 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | 0.929 |
CST1 | CTSS | ENSP00000305731 | ENSP00000357981 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. | 0.447 |
CST1 | LCN1 | ENSP00000305731 | ENSP00000263598 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family. | 0.488 |
CST1 | STATH | ENSP00000305731 | ENSP00000246895 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface. | 0.582 |
CST2 | CST1 | ENSP00000307540 | ENSP00000305731 | Cystatin-SA; Thiol protease inhibitor. | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | 0.999 |
CST2 | CST4 | ENSP00000307540 | ENSP00000217423 | Cystatin-SA; Thiol protease inhibitor. | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | 0.785 |
CST2 | CTSB | ENSP00000307540 | ENSP00000345672 | Cystatin-SA; Thiol protease inhibitor. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | 0.431 |
CST2 | CTSS | ENSP00000307540 | ENSP00000357981 | Cystatin-SA; Thiol protease inhibitor. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. | 0.506 |
CST2 | LCN1 | ENSP00000307540 | ENSP00000263598 | Cystatin-SA; Thiol protease inhibitor. | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family. | 0.435 |
CST2 | STATH | ENSP00000307540 | ENSP00000246895 | Cystatin-SA; Thiol protease inhibitor. | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface. | 0.400 |
CST4 | AMY1B | ENSP00000217423 | ENSP00000330484 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.764 |
CST4 | CST1 | ENSP00000217423 | ENSP00000305731 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. | 0.929 |