node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AWAT2 | CMC2 | ENSP00000421172 | ENSP00000219400 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates. | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | 0.666 |
AWAT2 | ICAM1 | ENSP00000421172 | ENSP00000264832 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates. | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. | 0.892 |
AWAT2 | NSL1 | ENSP00000421172 | ENSP00000355944 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates. | Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. | 0.726 |
AWAT2 | PROCR | ENSP00000421172 | ENSP00000216968 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates. | Endothelial protein C receptor; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. | 0.634 |
CHCHD7 | CMC2 | ENSP00000306425 | ENSP00000219400 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | 0.744 |
CHCHD7 | CMC4 | ENSP00000306425 | ENSP00000358496 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | 0.535 |
CHCHD7 | COA4 | ENSP00000306425 | ENSP00000443795 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Putative COX assembly factor; Belongs to the COA4 family. | 0.694 |
CHCHD7 | COA6 | ENSP00000306425 | ENSP00000355574 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.742 |
CHCHD7 | COX17 | ENSP00000306425 | ENSP00000261070 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.860 |
CHCHD7 | COX19 | ENSP00000306425 | ENSP00000342015 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity). Belongs to the COX19 family. | 0.820 |
CMC2 | AWAT2 | ENSP00000219400 | ENSP00000421172 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates. | 0.666 |
CMC2 | CHCHD7 | ENSP00000219400 | ENSP00000306425 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | 0.744 |
CMC2 | CMC4 | ENSP00000219400 | ENSP00000358496 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | 0.831 |
CMC2 | COA4 | ENSP00000219400 | ENSP00000443795 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Putative COX assembly factor; Belongs to the COA4 family. | 0.776 |
CMC2 | COA6 | ENSP00000219400 | ENSP00000355574 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.703 |
CMC2 | COX17 | ENSP00000219400 | ENSP00000261070 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.682 |
CMC2 | COX19 | ENSP00000219400 | ENSP00000342015 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity). Belongs to the COX19 family. | 0.727 |
CMC2 | ICAM1 | ENSP00000219400 | ENSP00000264832 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. | 0.823 |
CMC2 | NSL1 | ENSP00000219400 | ENSP00000355944 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. | 0.876 |
CMC2 | PROCR | ENSP00000219400 | ENSP00000216968 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Endothelial protein C receptor; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. | 0.928 |