node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBFA2T3 | WFDC1 | ENSP00000268679 | ENSP00000456920 | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.460 |
CDH13 | WFDC1 | ENSP00000268613 | ENSP00000456920 | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.503 |
HTRA3 | WFDC1 | ENSP00000303766 | ENSP00000456920 | Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. [...] | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.469 |
PROS1 | WFDC1 | ENSP00000377783 | ENSP00000456920 | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.532 |
SLPI | WFDC1 | ENSP00000342082 | ENSP00000456920 | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...] | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.646 |
SORBS2 | WFDC1 | ENSP00000347852 | ENSP00000456920 | Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.590 |
WFDC1 | CBFA2T3 | ENSP00000456920 | ENSP00000268679 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | 0.460 |
WFDC1 | CDH13 | ENSP00000456920 | ENSP00000268613 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. | 0.503 |
WFDC1 | HTRA3 | ENSP00000456920 | ENSP00000303766 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. [...] | 0.469 |
WFDC1 | PROS1 | ENSP00000456920 | ENSP00000377783 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. | 0.532 |
WFDC1 | SLPI | ENSP00000456920 | ENSP00000342082 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...] | 0.646 |
WFDC1 | SORBS2 | ENSP00000456920 | ENSP00000347852 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. | 0.590 |
WFDC1 | WFDC11 | ENSP00000456920 | ENSP00000348968 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | Protein WFDC11; WAP four-disulfide core domain 11. | 0.411 |
WFDC11 | WFDC1 | ENSP00000348968 | ENSP00000456920 | Protein WFDC11; WAP four-disulfide core domain 11. | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. | 0.411 |