node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNPY3 | GML | ENSP00000361926 | ENSP00000220940 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.481 |
CNPY3 | LRIG3 | ENSP00000361926 | ENSP00000326759 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | 0.493 |
CNPY3 | LRRC40 | ENSP00000361926 | ENSP00000359990 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.818 |
CNPY4 | GML | ENSP00000262932 | ENSP00000220940 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.573 |
CNPY4 | LRIG3 | ENSP00000262932 | ENSP00000326759 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | 0.457 |
CNPY4 | LRRC40 | ENSP00000262932 | ENSP00000359990 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.445 |
GML | CNPY3 | ENSP00000220940 | ENSP00000361926 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | 0.481 |
GML | CNPY4 | ENSP00000220940 | ENSP00000262932 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.573 |
GML | LRIG3 | ENSP00000220940 | ENSP00000326759 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | 0.548 |
GML | LRRC40 | ENSP00000220940 | ENSP00000359990 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.609 |
GML | LY6L | ENSP00000220940 | ENSP00000455811 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Lymphocyte antigen 6 family member L. | 0.571 |
GML | LYPD4 | ENSP00000220940 | ENSP00000476510 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | LY6/PLAUR domain containing 4. | 0.496 |
GML | PATE2 | ENSP00000220940 | ENSP00000351325 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Prostate and testis expressed 2. | 0.456 |
GML | PATE3 | ENSP00000220940 | ENSP00000395505 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Prostate and testis expressed 3; Belongs to the PATE family. | 0.522 |
GML | PINLYP | ENSP00000220940 | ENSP00000479240 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family. | 0.479 |
GML | TP53 | ENSP00000220940 | ENSP00000269305 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.495 |
LRIG3 | CNPY3 | ENSP00000326759 | ENSP00000361926 | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | 0.493 |
LRIG3 | CNPY4 | ENSP00000326759 | ENSP00000262932 | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.457 |
LRIG3 | GML | ENSP00000326759 | ENSP00000220940 | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.548 |
LRRC40 | CNPY3 | ENSP00000359990 | ENSP00000361926 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | 0.818 |