node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FHL2 | STX11 | ENSP00000386892 | ENSP00000356540 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | 0.881 |
FHL2 | STX19 | ENSP00000386892 | ENSP00000320679 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | 0.512 |
FHL2 | STXBP2 | ENSP00000386892 | ENSP00000413606 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. | 0.885 |
FHL2 | UNC13D | ENSP00000386892 | ENSP00000207549 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells. | 0.838 |
STX11 | FHL2 | ENSP00000356540 | ENSP00000386892 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.881 |
STX11 | STX19 | ENSP00000356540 | ENSP00000320679 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | 0.903 |
STX11 | STX1A | ENSP00000356540 | ENSP00000222812 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.593 |
STX11 | STX2 | ENSP00000356540 | ENSP00000376178 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.580 |
STX11 | STX3 | ENSP00000356540 | ENSP00000338562 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.745 |
STX11 | STX4 | ENSP00000356540 | ENSP00000317714 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.641 |
STX11 | STXBP2 | ENSP00000356540 | ENSP00000413606 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. | 0.999 |
STX11 | UNC13D | ENSP00000356540 | ENSP00000207549 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells. | 0.990 |
STX11 | VAMP2 | ENSP00000356540 | ENSP00000418572 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. | 0.966 |
STX11 | VAMP8 | ENSP00000356540 | ENSP00000263864 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.990 |
STX19 | FHL2 | ENSP00000320679 | ENSP00000386892 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.512 |
STX19 | STX11 | ENSP00000320679 | ENSP00000356540 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | 0.903 |
STX19 | STX1A | ENSP00000320679 | ENSP00000222812 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.568 |
STX19 | STX2 | ENSP00000320679 | ENSP00000376178 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.592 |
STX19 | STX3 | ENSP00000320679 | ENSP00000338562 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.735 |
STX19 | STX4 | ENSP00000320679 | ENSP00000317714 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.613 |