node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR3 | CLC | ENSP00000441600 | ENSP00000221804 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.765 |
CCR3 | IL5RA | ENSP00000441600 | ENSP00000412209 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | Interleukin-5 receptor subunit alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5; Belongs to the type I cytokine receptor family. Type 5 subfamily. | 0.806 |
CCR3 | RNASE2 | ENSP00000441600 | ENSP00000303276 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities; Belongs to the pancreatic ribonuclease family. | 0.542 |
CCR3 | RNASE3 | ENSP00000441600 | ENSP00000302324 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. | 0.581 |
CLC | CCR3 | ENSP00000221804 | ENSP00000441600 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.765 |
CLC | GALE | ENSP00000221804 | ENSP00000483375 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | 0.932 |
CLC | IGHV3-16 | ENSP00000221804 | ENSP00000478725 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate to the synthesis of a productive immunoglobulin chain due to altered V- (D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bou [...] | 0.900 |
CLC | IGHV3-43D | ENSP00000221804 | ENSP00000481152 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Immunoglobulin heavy variable 3-43D; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | 0.900 |
CLC | IGLL5 | ENSP00000221804 | ENSP00000431254 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Immunoglobulin lambda like polypeptide 5. | 0.907 |
CLC | IL5RA | ENSP00000221804 | ENSP00000412209 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Interleukin-5 receptor subunit alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5; Belongs to the type I cytokine receptor family. Type 5 subfamily. | 0.640 |
CLC | LGALS12 | ENSP00000221804 | ENSP00000339374 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.652 |
CLC | LGALS2 | ENSP00000221804 | ENSP00000215886 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known. | 0.709 |
CLC | RNASE2 | ENSP00000221804 | ENSP00000303276 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities; Belongs to the pancreatic ribonuclease family. | 0.758 |
CLC | RNASE3 | ENSP00000221804 | ENSP00000302324 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. | 0.708 |
GALE | CLC | ENSP00000483375 | ENSP00000221804 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.932 |
IGHV3-16 | CLC | ENSP00000478725 | ENSP00000221804 | Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate to the synthesis of a productive immunoglobulin chain due to altered V- (D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bou [...] | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.900 |
IGHV3-16 | IGHV3-43D | ENSP00000478725 | ENSP00000481152 | Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate to the synthesis of a productive immunoglobulin chain due to altered V- (D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bou [...] | Immunoglobulin heavy variable 3-43D; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | 0.953 |
IGHV3-16 | IGLL5 | ENSP00000478725 | ENSP00000431254 | Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate to the synthesis of a productive immunoglobulin chain due to altered V- (D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bou [...] | Immunoglobulin lambda like polypeptide 5. | 0.954 |
IGHV3-43D | CLC | ENSP00000481152 | ENSP00000221804 | Immunoglobulin heavy variable 3-43D; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.900 |
IGHV3-43D | IGHV3-16 | ENSP00000481152 | ENSP00000478725 | Immunoglobulin heavy variable 3-43D; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate to the synthesis of a productive immunoglobulin chain due to altered V- (D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bou [...] | 0.953 |